1 June 1991

Jan D. Blankensteijn, Onno T. Terpstra – 1 June 1991

Bud C. Tennant, N. Mrosovsky, Kirsteen McLean, Paul J. Cote, Brent E. Korba, Ronald E. Engle, John L. Gerin, Janet Wright, Gail R. Michener, Elizabeth Uhl, John M. King – 1 June 1991 – During studies of seasonal obesity, a high frequency of hepatic neoplasms was observed in Richardson's ground squirrels. Of 12 Richardson's ground squirrels examined thoroughly, 7 had mild or moderate degrees of chronic portal hepatitis and 6 (50%) had hepatocellular carcinoma.

Hervé Desmorat, Jean‐Pierre Vinel, Omar Lahlou, Bernard Pipy, Philippe Badia, Paul Cales, Jean‐Marc Combis, Marie‐Claude Souqual, Jean‐Pierre Pascal – 1 June 1991 – Molsidomine, a long‐acting vasodilator mainly used as an antianginal agent, was reported to decrease the portohepatic venous pressure gradient in patients with alcoholic cirrhosis. This study investigated the effects of linsidomine, the active metabolite of molsidomine, on systemic and splanchnic hemodynamics in rats with CCI4‐induced cirrhosis using the microsphere technique.

Preston F. Foster, Achyut Bhattacharyya, Howard N. Sankary, James Coleman, Marilyn Ashmann, James W. Williams – 1 June 1991 – Although it is known that eosinophils consistently infiltrate rejecting human liver allografts, their function is unknown. Infiltrating eosinophils can release a cytotoxic substance, eosinophil cationic protein. Furthermore, eosinophil cationic protein may be identified in biopsy specimens using immunoperoxidase staining of an eosinophil cationic protein‐specific monoclonal antibody.

Lea‐Yea Chuang, Juei‐Hsiung Tsai, Yun‐Chi Yeh, Chun‐Chang Chang, Hsing‐Wu Yeh, Jinn‐Yuh Guh, Jung‐Fa Tsai – 1 June 1991 – To characterize epidermal growth factor–related transforming growth factors in the urine of patients with hepatocellular carcinoma, gel filtration with Bio‐Gel P‐30 was performed in seven hepatocellular carcinoma patients and seven sex‐matched and age‐matched healthy controls. Distinct profiles of soft agar growth assay in the hepatocellular carcinoma patients and the normal controls were seen. Three peaks (A, B and C) in the urine were examined.

S. Bresson‐Hadni, A. Franza, J. P. Miguet, D. A. Vuitton, D. Lenys, E. Monnet, G. Landecy, G. Paintaud, P. Rohmer, M. C. Becker, J. L. Christophe, G. Mantion, M. Gillet – 1 June 1991 – Between 1986 and 1989, orthotopic liver transplantations were performed in our unit for 17 patients with incurable alveolar echinococcosis. Ten patients had hilar involvement (group I), and seven patients had posterior localization (five of them had chronic Budd‐Chiari syndrome) (group II).

Janna C. Collins – 1 June 1991

James Yarbrough, Michael Cunningham, Hirofumi Yamanaka, Ronald Thurman, Mostafa Badr – 1 June 1991 – Liver regeneration after partial hepatectomy is accompanied by altered hepatic intermediary metabolism. Because the organochlorine compound mirex also causes liver cell growth, the purpose of this study was to investigate hepatic carbohydrate and oxygen metabolism in perfused livers from mirex‐treated rats and to localize cell proliferation in this model.

Sheri Zidenberg‐Cherr, Katherine L. Olin, Jesus Villanueva, Anna Tang, Stephen D. Phinney, Charles H. Halsted, Carl L. Keen – 1 June 1991 – In the miniature pig, ethanol consumption has been reported to induce alterations in hepatic antioxidant defense capacity, which could result in increased risk of peroxidative damage. However, ethanol may also induce changes in membrane fatty acid composition, which could reduce the risk of peroxidative damage.