Noboru Hirooka, Yoshiro Nitta, Takabumi Tsunoda, Eiji Kitazawa, Junichi Sato, Akira Machii, Yoshitsugu Murakami, Manabu Takahashi, Fukuo Kondo – 1 August 1990 – A microscopic atypical focus suggestive of hepatocellular carcinoma is reported. The lesion, 0.3 mm in diameter, was found by chance in a liver biopsy specimen taken from a cirrhotic patient; it was characterized histologically by cytoplasmic basophilia, hypercellularity (high nucleus‐to‐cell ratio) and microacinar structures.

Fred M. Hunter – 1 August 1990

Michael A. Gerber, Jerome D. Waye – 1 August 1990

Hamish H. Hart – 1 August 1990 – Liver abscesses due to Yersinia enterocolitica usually occur in patients with a pathological iron overload. A case of multiple liver abscesses in a patient with haemochromatosis is reported and the literature is reviewed.

Harold O. Conn, C. N. Ghent – 1 August 1990 – S‐Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12‐2H]chenodeoxycholic acid and [24‐13C]cholic acid were determined before and after treatment with S‐adenosylmethionine. S‐Adenosylmethionine did not ameliorate symptoms or biochemical parameters of cholestasis but reduced bile acid clearances in 3 of 4 subjects.

Eric B. Rypins, I. James Sarfeh – 1 August 1990 – To test the hypothesis that partial portal decompression in the treatment of variceal hemorrhage will diminish subsequent encephalopathy, 50 consecutive patients were studied after construction of a small‐stoma (10 to 12 mm) side‐to‐side portacaval shunt, with the goal of a postoperative portacaval pressure gradient of 10 mm Hg. During follow‐up averaging 26 months, six patients (12 percent) died. Four patients (8 percent) had episodes of rebleeding, only one from varices.

Sandro Gentile, Marcello Persico, Claudio Tiribelli – 1 August 1990 – The plasma disappearance rate of sulfobromophthalein (VBSP; μmol/kg/min) was measured in 15 Gilbert's syndrome patients and 12 control subjects after intravenous injection of two different doses (0.59 and 5.90 μmol/kg) of the dye. Plasma disappearance rate was significantly reduced in Gilbert's syndrome patients after administration of 0.59 μmol sulfobromophthalein/kg (0.119 ± 0.016 vs. 0.146 ± 0.018 μmol/kg/min; mean ± S.D.; p < 0.001), whereas no difference was found with the higher dose (0.754 ± 0.040 vs.

Santiago J. Muñoz, Antonino Martinez‐Hernandez, Willis C. Maddrey – 1 August 1990 – Although liver injury after administration of the trimethoprim‐sulfamethoxazole combination is rare, hepatocellular necrosis and cholestasis have developed in a few cases. We describe a patient who developed a severe, prolonged cholestatic reaction after trimethoprim‐sulfamethoxazole administration. The findings from serial liver biopsy samples showed characteristic abnormalities of phospholipidosis that have not been previously described for trimethoprimsulfamethoxazole–related hepatic injury.

Karl‐Hermann Meyer Zum Büschenfelde, Ansgar W. Lohse, Michael Manns, Thomas Poralla – 1 August 1990

Reinhild Klein, Peter A. Berg – 1 August 1990 – Sera from 81 healthy family members (including husbands) of 13 patients with primary biliary cirrhosis were tested by Western blotting against the antigen fractions M9 and M2 derived respectively from rat liver and beef heart mitochondria. Fifty‐eight (70%) were positive and recognized four major (molecular weights 98 kD, 65 kD, 61 kD, 58 kD) and eight minor determinants (85 kD, 81 kD, 78 kD, 54 kD, 48 kD, 45 kD, 40 kD, 30 kD) labeled α‐my. Each of the 58 sera recognized at least one of the four major polypeptides.