Leonard C. Warner, Peter J. Campbell, Gilles A. Morali, Alexander G. Logan, Karl L. Skorecki, Laurence M. Blendis – 1 September 1990 – Despite intensive investigation, the pathogenesis of sodium retention in patients with chronic liver disease is not fully known. We have studied 19 chronic liver disease patients, 13 without (group 1) and six with (group 2) histories of clinical sodium retention (ascites or edema) by varying dietary sodium intake.

Dominique Vuitton – 1 September 1990 – The efficacy of albendazole (50 mg/kg/d), mebendazole (50 mg/kg/d) and praziquantel (500 mg/kg/d) against established intraperitoneal infections of Echinococcus multilocularis in gerbils was compared by monitoring parasite weight and making ultrastructural observations on treated and untreated material. Praziquantel was the most active protoscolicidal agent, reducing protoscolex viability to <2%, although it did not inhibit cyst growth.

Telfer B. Reynolds – 1 September 1990 – Study Objective: To determine the efficacy of a corticosteroid in reducing the short‐term mortality of patients with 8evere alcoholic hepatitis.

David A. Gremse, Hassan H. A‐Kader, Timothy J. Schroeder, William F. Balistreri – 1 September 1990 – Lidocaine, an aminoethylamide, undergoes deethylation in the liver after intravenous injection, resulting in the formation of monoethylglycinexylidide. Serum monoethylglycinexylidide concentration can be measured by a simple, rapid fluorescent polarization immunoassay. We sought to determine whether lidocaine metabolism, as indicated by monoethylglycinexylidide formation, could be used as a quantitative index of hepatic function.

Scott L. Friedman – 1 September 1990

David H. Van Thiel, Rudolf E. Stauber, Judith S. Gavaler, Elaine Rosenblum – 1 September 1990 – Animals with end‐to‐side portacaval shunts and sham‐operated animals, wherein the body weight and liver weight of the animals varied spontaneously over a considerable range, were studied. The relationships between hepatic androgen‐ and estrogen‐receptor content, serum testosterone and estradiol levels and hepatic mass were characterized. Animals with portacaval shunts were smaller than those without shunts. Moreover, they had reduced serum levels of testosterone and estradiol.

Hidekazu Tsukamoto, Karl Gaal, Samuel W. French – 1 September 1990

Christine Silvain, Eric Fort, Pierre Ingrand, Michel Beauchant, Jorge E. Valenzuela, Timothy Schubert, James Posillico, Loren Laine – 1 September 1990

Samuel S. Lee, Jean Marty, Jean Mantz, Emmanuel Samain, Alain Braillon, Didier Lebrec – 1 September 1990 – Cardiac responses to catecholamines are known to be attenuated in chronic liver disease. To elucidate the role of β‐adrenergic receptor alteration in this phenomenon, we measured heart rate responsiveness to isoprenaline and myocardial β‐adrenergic receptor–binding characteristics in three groups of rats: those that were sham operated, those that had portal vein stenosis and those that were cirrhotic because of bile duct ligation.

Teresa L. Wright, John R. Lake – 1 September 1990 – Although most iron in plasma is bound to transferrin, recent evidence suggests that the nontransferrin‐bound fraction contributes to hepatic iron loading and toxicity seen in iron‐overload disorders. Our studies of isolated perfused rat liver previously demonstrated saturable uptake of nontransferrin‐bound iron that continues despite hepatic iron overload.