Robert L. Stahl, Alexander Duncan, Michael A. Hooks, J. Michael Henderson, William J. Millikan, W. Dean Warren – 1 September 1990 – Orthotopic liver transplantation may be associated during the postoperative period with hepatic artery thrombosis, a catastrophic occurrence generally necessitating emergency retransplantation. To assess the contribution of the coagulation mechanism to this complication, the levels of procoagulant and anticoagulant proteins were followed in 41 liver transplant patients during the first 10 postoperative days.

Stephan Krählenbühl, Jürg Reichen, Arthur Zimmermann, Peter Gehr, Jörg Stucki – 1 September 1990 – To investigate whether the impairment of mitochondrial function in cirrhosis is due to a reduction in liver cell mass or whether mitochondrial function is altered specifically, we analyzed mitochondrial volume and surface density of mitochondrial membranes in control and cirrhotic rats by stereological means. Cirrhosis was induced by long‐term exposure to phenobarbital and CC14.

Shimon Reif, Victor P. Terranova, Mamdouh El‐Bendary, Emanuel Lebenthal, James K. Petell – 1 September 1990 – The expression and localization of extracellular matrix proteins in rat liver was investigated as a function of liver development. Levels of extracellular matrix proteins were measured by dot‐blot or immunoblot protocols using monospecific antibodies prepared against collagen types I, III and IV; laminin; fibronectin; and fibronectin receptor. Proline and hydroxyproline levels from extracted liver collagen were quantitated by Pico Tag analysis.

1 September 1990

Douglas Simon, Lawrence J. Brandt – 1 September 1990 – Endoscopic retrograde cholangiopancreatography (ERCP) was performed in twenty‐six AIDS patients to evaluate either abdominal pain suggestive of biliary tract disease, fever, serum alkaline phosphatase elevation, or a combination of these findings. Twenty patients (77%) had abnormal cholangiograms and four distinct patterns were identified: (1) papillary stenosis (n = 3); (2) sclerosing cholangitis (n = 4); (3) sclerosing cholangitis with papillary stenosis (n = 10); and (4) long extrahepatic bile duct strictures (n = 3).

Gearld Y. Minuk, Tony Gauthier, Abraham Benarroch – 1 September 1990 – Polyamines have been reported to play an important role in stimulating hepatic regeneration after partial hepatectomy. To determine whether changes in systemic or hepatic polyamine concentrations correlate with the extent of the regenerative stimulus, serum and tissue putrescine, spermidine and spermine concentrations were determined in groups of adult male rats (n = 6 to 12/group) 0, 24, 48, and 72 hr after 30%, 70% or 90% partial hepatectomy.

William G. Rector, Frederick Lewis, Alastair D. Robertson, Gregory T. Everson – 1 September 1990 – The aim of this study was to determine whether liver function and portosystemic shunting are related to renal sodium retention in alcoholic liver disease. Twenty‐three studies were performed; 10 patients had ascites. Liver function was assessed from the plasma elimination rates of antipyrine, caffeine and stable isotopes of cholic acid, the latter administered both orally [2,2,4,4‐2H] and intravenously [24‐13C].

1 August 1990

Rolando Hernández‐muñoz, Mauricio Díaz‐muñoz, Jorge Suárez, Victoria Chagoya de Sánchez – 1 August 1990 – Adenosine administration was tested in rats with carbon tetrachloride–induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin. This amelioration of the hepatomegaly was accompanied by a 50% reduction of the liver collagen deposition and preservation of content of glycosaminoglycans. A stimulated hepatic collagenase activity is apparently the mechanism for reduction of collagen accumulation.

Shuhei Nishiguchi, Tetsuo Kuroki, Tadashi Takeda, Shinya Nakajima, Susumu Shiomi, Shuichi Seki, Isao Matsui‐Yuasa, Shuzo Otani, Kenzo Kobayashi – 1 August 1990 – We studied the effects of putrescine on acute liver failure caused in rats by two injections of 1 gm/kg D‐galactosamine. The hepatic polyamine level rose only slightly in the D‐galactosamine–injected rats treated with glucagon and insulin, and [3H]thymidine incorporation into DNA increased little; these hormones did not improve the survival rate.