Abstracts of the iasl biennial meeting
1 August 1990
Immunohistochemistry of the hepatic extracellular matrix in acute viral hepatitis
Sadataka Inuzuka, Takato Ueno, Takuji Torimura, Michio Sata, Hirohiko Abe, Kyuichi Tanikawa – 1 August 1990 – The distribution of several extracellular matrix components in the liver of patients with acute viral hepatitis was studied by light and electron microscopy using indirect immunoperoxidase methods.
Detection of antibodies against the polymerase gene product in hepatitis B virus infection
Nobukazu Yuki, Norio Hayashi, Akinori Kasahara, Kazuhiro Katayama, Keiji Ueda, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1990 – We have studied antibodies (anti‐pol antibody) against the polymerase gene product of hepatitis B virus by solid‐phase enzyme immunoassay using synthetic peptides coded for by this gene. Sera from six patients with acute hepatitis B, 112 chronic hepatitis B virus carriers and six healthy individuals with naturally acquired immunity to hepatitis B virus were tested for anti‐pol antibody.
Lack of metabolic effects of cholecystokinin on hepatocytes
Louis J. Kost, Gregory J. Gores, John M. Sayles, Laurence J. Miller, John J. Lemasters, Brian Herman, Nicholas F. Larusso – 1 August 1990 – We previously reported that the liver was the major organ that extracts small, biologically active, circulating forms of cholecystokinin. Although our work indicated extensive degradation of cholecystokinin extracted from plasma during its transit across the hepatocyte, it was unclear whether cholecystokinin might also have a physiological effect on this cell before its intracellular degradation.
Microscopic incipient hepatocellular carcinoma found incidentally in a routine liver biopsy specimen
Noboru Hirooka, Yoshiro Nitta, Takabumi Tsunoda, Eiji Kitazawa, Junichi Sato, Akira Machii, Yoshitsugu Murakami, Manabu Takahashi, Fukuo Kondo – 1 August 1990 – A microscopic atypical focus suggestive of hepatocellular carcinoma is reported. The lesion, 0.3 mm in diameter, was found by chance in a liver biopsy specimen taken from a cirrhotic patient; it was characterized histologically by cytoplasmic basophilia, hypercellularity (high nucleus‐to‐cell ratio) and microacinar structures.
ERCP atlas. by G. Pott and B. Schrameyer, 227 pp. St. Louis: Mosby‐Year Book, Inc., 1989. $79.50
Michael A. Gerber, Jerome D. Waye – 1 August 1990
The potentiation of yersinial infections in iron storage disorders
Hamish H. Hart – 1 August 1990 – Liver abscesses due to Yersinia enterocolitica usually occur in patients with a pathological iron overload. A case of multiple liver abscesses in a patient with haemochromatosis is reported and the literature is reviewed.
Benign recurrent intrahepatic cholestasis: Failure of S‐adenosylmethionine therapy
Harold O. Conn, C. N. Ghent – 1 August 1990 – S‐Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12‐2H]chenodeoxycholic acid and [24‐13C]cholic acid were determined before and after treatment with S‐adenosylmethionine. S‐Adenosylmethionine did not ameliorate symptoms or biochemical parameters of cholestasis but reduced bile acid clearances in 3 of 4 subjects.