Staffan Johansson, Niclas Andersson, Göran Andersson – 1 September 1990 – We studied the regulation of the epidermal growth factor receptor mRNA and the number of epidermal growth factor binding sites in subcellular compartments involved in the biosynthesis and endocytosis of the epidermal growth factor receptor during the prereplicative phase of liver regeneration. The epidermal growth factor receptor mRNA, quantified by solution hybridization, decreased after partial hepatectomy, with a nadir of about 35% 18 hr after hepatectomy.

Fuad Hasan, Lennox J. Jeffers, Maria De Medina, K. Rajender Reddy, Talley Parker, Eugene R. Schiff, Michael Houghton, Quilim Choo, George Kuo – 1 September 1990 – In the United States, a large percentage of patients with hepatocellular carcinoma are serologically negative for hepatitis B.

Adolf Stiehl, Gerda Rudolph, Richard Raedsch, Bernd Moller, Ulrich Hopf, Erich Lotterer, Johannes Bircher, Ulrich Fölsch, Jürgen Klaus, Richard Endele, Martin Senn – 1 September 1990 – Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied.

1 September 1990

Michael A. Gerber, Frank L. Iber – 1 September 1990

Harold O. Conn, Ronald L. Koretz – 1 September 1990 – Chronic hepatitis C (non‐A, non‐B hepatitis) is a common and often progressive viral liver disease. To assess the efficacy of therapy with the antiviral agent interferon alfa, we randomly assigned 166 patients with chronic hepatitis C to treatment with either 3 million or 1 million units of recombinant interferon alfa three times weekly for 24 weeks, or to no treatment.

Han Moshage, Alessandro Casini, Charles S. Lieber – 1 September 1990 – Hepatocytes and fat‐storing cells have been implicated in the production of collagen, under both normal and pathological conditions. In this study, short‐term primary cultures of rat hepatocytes, maintained in a serum‐free, hormonally defined medium without dexamethasone and cultured on a fibronectin‐collagen type IV substratum, were used. Primary and passage 1 and 2 cultures of fat‐storing cells maintained on tissue culture plastic were also studied.

R. Shields, S. A. Jenkins – 1 September 1990

Peter R. Galle, Lorenz Theilmann, Richard Raedsch, Gerd Otto, Adolf Stiehl – 1 September 1990 – Primary human hepatocytes were used to study bile salt hepatotoxicity and the hepatoprotective potential of ursodeoxycholate in vitro. Hepatocytes were obtained by collagenase perfusion of healthy human liver tissue and were treated with glycochenodeoxycholate for 24 hr 1 day after plating. Clear signs of cytotoxicity were observed at concentrations of about 100 μmol/L glycochenodeoxycholate.

Josep M. Piqué, Pilar Pizcueta, ROSA M. Pérez Ayuso, Jaime Bosch – 1 September 1990 – Rats with chronic portal hypertension have an increased gastric mucosal blood flow and an impaired acid secretory response to pentagastrin stimulation. This study investigated the effects of propranolol, a drug widely used in the treatment of portal hypertension, on gastric mucosal blood flow and acid secretion in portal hypertensive rats with partial portal vein occlusion.