Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis B virus infection in children

Ping‐Ing Lee, Mei‐Hwei Chang, Chin‐Yun Lee, Hong‐Yuan Hsu, Juei‐San Chen, Pei‐Jer Chen, Ding‐Shinn Chen – 1 October 1990 – During a follow‐up period of 3.2 ± 1.6 (1 to 8.6) yr, 1,087 serum specimens from 230 HBsAg carrier children were tested for hepatitis B virus markers.

Prognostic factors of hepatocellular carcinoma in the west: A multivariate analysis in 206 patients

Xavier Calvet, Jordi Bruix, Pere Ginés, Concepció Bru, Manel Sole, Ramón Vilana, Joan Rodés – 1 October 1990 – To investigate the prognostic factors in Western patients with hepatocellular carcinoma, 206 patients with confirmed diagnoses of hepatocellular carcinoma were studied in terms of survival. All patients were diagnosed between 1983 and 1987.

Relative frequencies of portosystemic pathways and renal shunt formation through the “posterior” gastric vein: Portographic study in 460 patients

Kunio Kimura, Masao Ohto, Shoichi Matsutani, Junji Furuse, Kazuhiko Hoshin, Kunio Okuda – 1 October 1990 – Percutaneous transhepatic portography was carried out in 460 patients with portal hypertension to study various collateral routes. Besides the left gastric vein, which was the most frequent collateral route and feeder of esophageal varices, a distinct vein located between the left gastric vein and the short gastric vein constituted a major collateral route in 191 patients (42%).

Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis

Hiroko Oka, Narito Kurioka, Kosyun Kim, Toru Kanno, Tetsuo Kuroki, Yasuhiro Mizoguchi, Kenzo Kobayashi – 1 October 1990 – We prospectively monitored 140 cirrhotic patients for the development of hepatocellular carcinoma for 6 yr, using periodical screening by high‐resolution convex‐array ultrasonography and α‐fetoprotein. Twenty‐eight patients were positive for HBs antigen, 26 patients had received blood transfusions and were negative for HBs antigen and 26 patients had a history of heavy drinking. We detected hepatocellular carcinoma in 40 patients during this period.

Endoscopic ligation of esophageal varices: An endoscopist's opinion

Francis J. Tedesco – 1 October 1990 – One hundred consecutive patients with bleeding esophageal varices were treated with a new endoscopic ligating device that effects strangulation of varices using small elastic “O” rings. Treatments were continued after initial hospitalization to achieve variceal eradication. Follow‐up ranged from 6 to 26 (mean: 15) months. Bleeding was controlled until discharge from hospital or death in 18 of 21 patients who were actively bleeding at index endoscopy. Overall, 26 patients died during the study, 12 during the index hospitalization.

Hepatocyte plasma membrane glycosphingolipid reactive with sera from patients with autoimmune chronic active hepatitis: Its identification as sulfatide

Gotaro Toda, Yusei Ikeda, Masuo Kashiwagi, Masao Iwamori, Hiroshi Oka – 1 October 1990 – Sera from patients with autoimmune chronic active hepatitis were found to contain IgG‐class antibody to the acidic glycosphingolipid fraction from rabbit hepatocyte plasma membrane by solid‐phase enzyme‐linked immunosorbent assay. Using serum positive for the antibody as a probe, we isolated the target antigen by Iatrobeads column chromatography. Analysis by thinlayer chromatography and negative ion fast atombombardment mass spectrometry revealed that the antigen was sulfatide.

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