Amyloid deposition in intrahepatic large bile ducts and peribiliary glands in systemic amyloidosis

Motoko Sasaki, Yasuni Nakanuma, Tadashi Terada, Masahiro Hoso, Katsuhiko Saito, Morimoto Hayashi, Hiroshi Kurumaya – 1 October 1990 – Amyloid deposition in the hepatic parenchyma and portal tracts in the liver is well known in systemic amyloidosis. We recently experienced an autopsy case of systemic amyloidosis presenting the amyloid deposits in the intrahepatic biliary tree. This experience prompted us to survey 19 autopsy cases of systemic amyloidosis.

Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: Results of a double‐blind, placebo‐controlled trial

Pere Ginés, Antoni Rimola, Ramón Planas, Victor Vargas, Francesc Marco, Manuel Almela, Montserrat Forne, Maria Luisa Miranda, Josep Llach, Joan Manuel Salmerón, Maria Esteve, Josep Maria Marques, Maria Teresa Jiménez de Anta, Vicente Arroyo, Joan Rodés – 1 October 1990 – Eighty cirrhotic patients who had recovered from an episode of spontaneous bacterial peritonitis were included in a multicenter, double‐blind trial aimed at comparing long‐term norfloxacin administration (400 mg/day; 40 patients) vs. placebo (40 patients) in the prevention of spontaneous bacterial peritonitis recurrence.

Supplemental putrescine reverses ethanol‐associated inhibition of liver regeneration

Anna Mae Diehl, Suzan Abdo, Nesbitt Brown – 1 October 1990 – Biosynthesis of the polyamines, putrescine, spermidine and spermine, is required for DNA synthesis and liver regeneration after partial hepatectomy. Chronic ethanol consumption impairs polyamine synthesis during the prereplicative phase after partial hepatectomy. To determine whether this delay in polyamine synthesis contributes to ethanol's inhibition of liver regeneration, the ability of supplemental putrescine to improve regeneration in ethanol‐fed rats was tested.

Pretranslational and posttranslational regulation of the EGF receptor during the prereplicative phase of liver regeneration

Staffan Johansson, Niclas Andersson, Göran Andersson – 1 September 1990 – We studied the regulation of the epidermal growth factor receptor mRNA and the number of epidermal growth factor binding sites in subcellular compartments involved in the biosynthesis and endocytosis of the epidermal growth factor receptor during the prereplicative phase of liver regeneration. The epidermal growth factor receptor mRNA, quantified by solution hybridization, decreased after partial hepatectomy, with a nadir of about 35% 18 hr after hepatectomy.

Ursodeoxycholic acid–induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis

Adolf Stiehl, Gerda Rudolph, Richard Raedsch, Bernd Moller, Ulrich Hopf, Erich Lotterer, Johannes Bircher, Ulrich Fölsch, Jürgen Klaus, Richard Endele, Martin Senn – 1 September 1990 – Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied.

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