Douglas D. Dalke, Michael F. Sorrell, Carol A. Casey, Dean J. Tuma – 1 November 1990 – The effects of chronic ethanol administration on the receptor‐mediated endocytosis of epidermal growth factor were studied in isolated rat hepatocytes. In initial experiments, it was demonstrated that significantly less ligand was bound by hepatocytes isolated from rats fed an ethanol liquid diet for 5 to 7 wk than by cells isolated from chow‐fed or pair‐fed controls. Reduced binding was shown to be primarily caused by a decreased number of surface receptors rather than by changes in receptor affinity.

Stefan G. Hubscher, Mrcpath, Raouf E. Nakhleh, Dale C. Snover – 1 November 1990

Gordon Baskin – 1 November 1990

Douglas L. Schmucker, Minoru Ohta, Setsuko Kanai, Yuko Sato, Kenichi Kitani – 1 November 1990 – Continuous intravenous infusion of taurochenodeoxycholate at a rate of 0.4 μmol · min−1 · 100 gm−1 for only 30 min in rats caused threefold to tenfold greater release of proteins (alkaline phosphatase, lactate dehydrogenase and albumin) into bile in comparison with animals infused with tauroursodeoxycholate at much higher rates (1.8 μmol · min−1 · 100 gm−1) for 2 hr.

1 November 1990

Cornelis P. de Vries, Tien‐Chun Chang – 1 November 1990

Harold O. Conn – 1 November 1990 – After consuming comparable amounts of ethanol, women have higher blood ethanol concentrations than men, even with allowance for differences in size, and are more susceptible to alcoholic liver disease. Recently, we documented significant “first pass metabolism” of ethanol due to its oxidation by gastric tissue. We report a study of the possible contribution of this metabolism to the sex‐related difference in blood alcohol concentrations in 20 men and 23 women. Six in each group were alcoholics.

Misael Uribe, Octavio Campollo, Christiane Cote – 1 November 1990 – Short‐chain (C2C5) fatty acids account for 60%–70% of the anions in the colon. Acetate (C2) is nontoxic in contrast to C(3)4C5 fatty acids (propionate, butyrate, isobutyrate, valerate, and isovalerate), which induce coma in animals and may be important in the pathogenesis of hepatic coma in humans. An in‐vitro fecal incubation system was used to map out short‐chain fatty acid production in the presence of lactulose, amino acids, albumin, or blood. Albumin and blood increased production of all C2C5 fatty acids.

R. A. Willson – 1 November 1990 – 1.Patients with a history of alcohol abuse were studied by 31P n.m.r. spectroscopy of the liver in vivo, and the results were related to the pattern of disease assessed by standard biochemical and histological techniques.2.The ratios of metabolites measured from the 31P n.m.r. spectra were abnormal in patients with alcoholic hepatitis but not in those with fatty change or cirrhosis in the absence of hepatitis. In particular, the levels of phosphomonoesters were raised, with respect either to Pv, or to adenosine 5′‐triphosphate.

William R. Brown – 1 November 1990