Shinya Nakajima, Tetsuo Kuroki, Machiko Shintani, Osamu Kurai, Tadashi Takeda, Shuhei Nishiguchi, Susumu Shiomi, Shuichi Seki, Kenzo Kobayashi – 1 December 1990 – We studied the binding of 125I‐labeled human interferon‐α to peripheral blood mononuclear cells and the activity of 2′,5′‐oligoadenylate synthetase in peripheral blood mononuclear cells obtained from 21 patients with chronic hepatitis B who were treated with human interferon‐α or interferon‐β. Fourteen patients were given interferon daily for 4 wk.

Robert Wondergem – 1 December 1990 – In hepatocytes from fasted rats, several amino acids are known to stimulate glycogen synthesis via activation of glycogen synthase. The hypothesis that an increase in cell volume resulting from amino acid uptake may be involved in the stimulation of glycogen synthesis is supported by the following observations.

Luc Bouwens, Andreas Marinelli, Peter J. K. Kuppen, Alex M. M. Eggermont, Cornelis J. H. van de Velde, Eddie Wisse – 1 December 1990 – Treatment schedules were investigated for in vivo induction of lymphokine‐activated killer cells in the rat liver. Treatment of rats with continuous systemic or regional infusion of recombinant human interleukin‐2 with a dose of 4 to 8 × 104 U/day during 7 days, resulted in an increase in number of large granular lymphocytes or pit cells in the liver up to 43 times normal.

Kiyoshi Takeda, Yoshihiro Akahane, Hiroshi Suzuki, Hiroaki Okamoto, Fumio Tsuda, Yuzo Miyakawa, Makoto Mayumi – 1 December 1990 – Hepatitis B virus DNA clones were propagated from sera of six patients with chronic hepatitis B who seroconverted from HBeAg to antibody to HBeAg either spontaneously or after administration of α‐interferon. Defects in the precore region blocking synthesis and secretion of HBeAg were detected in all 46 hepatitis B virus DNA clones from three patients who remained positive for antibody to HBeAg and in whom hepatitis resolved.

1 December 1990

Hector Orrego, Laurence M. Blendis, Yedy Israel – 1 December 1990

Fredric Regenstein – 1 December 1990

Steven Schenker, S. Angela Khan – 1 December 1990

Claire Guyomard, Christophe Chesne, Bernard Meunier, Alain Fautrel, Catherine Clerc, Fabrice Morel, Maryvonne Rissel, Jean‐Pierre Campion, André Guillouzo – 1 December 1990 – Rat livers were perfused and stored for 48 hr in cold University of Wisconsin solution before dissociation by the two‐step collagenase method. At that time, glycogen content was significantly reduced, but no obvious changes in albumin, β‐actin and aldolase B mRNAs and in glutathione levels were observed. Enzymatic perfusion yielded 280 ± 30 × 106 viable hepatocytes vs.

Gloria Moraleda, Javier Bartolomé, Maria Gracia Martinez, Juan Carlos Porres, Vicente Carreño – 1 December 1990 – The presence of hepatitis B virus DNA was studied in peripheral blood mononuclear cell samples from 259 HBsAg carriers (229 anti‐hepatitis delta negative, 30 anti‐hepatitis delta positive), 16 anti‐HBc—positive HBsAg‐negative patients and 30 patients without hepatitis B virus markers.