A pilot, double‐blind, controlled 1‐year trial of prednisolone treatment in primary biliary cirrhosis: Hepatic improvement but greater bone loss

Harriet C. Mitchison, Margaret F. Bassendine, Archie J. Malcolm, Alex J. Watson, Christopher O. Record, Oliver F. W. James – 1 October 1989 – A randomized, double‐blind, 1‐year pilot study of prednisolone treatment for primary biliary cirrhosis was undertaken. Nineteen patients received 30 mg prednisolone per day initially, with a maintenance dose of 10 mg per day. Seventeen patients received placebo. The groups were matched for age, menopausal status, hepatic histological stage and bilirubin.

Taurocholate transport by basolateral plasma membrane vesicles isolated from human liver

Donald A. Novak, Frederick C. Ryckman, Frederick J. Suchy – 1 October 1989 – Transport of taurocholate into the hepatocyte against unfavorable chemical and electrical gradients occurs via a sodium‐dependent, carrier‐mediated transport system. Although this cotransporter has been characterized in the rodent, it has not been demonstrated in man. Therefore, we utilized human liver, obtained via multiorgan donation but not used for transplantation, to prepare basolateral (sinusoidal) liver plasma membrane vesicles by a Percoll gradient method.

Replication of duck hepatitis B virus in primary duck hepatocytes and its dependence on the state of differentiation of the host cell

Peter R. Galle, Hans‐jürgen Schlicht, Christa Kuhn, Heinz Schaller – 1 October 1989 – Primary duck hepatocytes obtained from Pekin ducks congenitally infected with duck hepatitis B virus were used to monitor expression of viral proteins and replication of viral DNA in cell culture. Duck hepatitis B virus core antigen, duck hepatitis B virus pre‐surface antigen and duck hepatitis B virus DNA were detectable for at least 12 days after cell plating.

Successful endoscopic obturation of gastric varices with butyl cyanoacrylate

Marie‐Jose Ramond, Dominique Valla, Jean‐François Mosnier, Claude Degott, Jacques Bernuau, Bernard Rueff, Jean‐Pierre Benhamou – 1 October 1989 – In 27 patients who had bled from esophagogastric varices, large‐sized and/or actively bleeding gastric varices were endoscopically obturated with the tissue adhesive butyl cyanoacrylate. Active bleeding was stopped in six patients.

Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis

Ashok K. Batta, Gerald Salen, Renu Arora, Sarah Shefer, G. Stephen Tint, John Abroon, David Eskreis, Seymour Katz – 1 October 1989 – We have compared the effect of ursodeoxycholic acid with placebo on the clinical state, blood liver chemistries and serum and urinary bile acids in four patients with primary biliary cirrhosis. All parameters were evaluated monthly, and bile acid composition was measured by capillary gas‐liquid chromatography.

Enterically transmitted non‐A, non‐B hepatitis: Recovery of virus–like particles from an epidemic in south delhi and transmission studies in rhesus monkeys

Subrat K. Panda, Rakesh Datta, Jagjit Kaur, Arie J. Zuckerman, Nabeen C. Nayak – 1 October 1989 – An epidemic of viral hepatitis, serologically characterized as due to non‐A, non‐B hepatitis, occurred in a village of South Delhi, India, in December, 1986, through January, 1987. Water contaminated with fecal matter was the apparent source of infection. Disease‐associated virus‐like particles were detected by immune electron microscopy in the feces of three patients within 5 days of illness.

Comparison of treatments of bleeding varices: Effects of differences between treatment intended and treatment received

Linda Rabeneck – 1 October 1989 – Ninety‐seven patients with recent or active var‐iceal bleeding were randomly assigned to oral pro‐pranolol, endoscopic sclerotherapy plus oral pro‐pranolol, or transhepatic sclerotherapy plus oral propranolol. The effects of treatment on the number of units transfused, rebleeding of any magnitude, major rebleeding, and death were assessed in these patients, 82% of whom were alcoholic and 81% Child's Class C.

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