Prevalence of hepatocellular carcinoma and relation to cirrhosis: Comparison of two different cities of the world—Trieste, Italy, and Chiba, Japan

Claudio Tiribelli, Mauro Melato, Lory S. Crocè, Luigi Giarelli, Kunio Okuda, Kunihiko Ohnishi – 1 December 1989 – A comparative, descriptive study on the prevalence of hepatocellular carcinoma either associated or not with cirrhosis was undertaken between the cities of Trieste, Italy, and Chiba, Japan. Data were derived from 12,340 and 2,052 autopsies consecutively performed in Trieste and Chiba during 1980 to 1984 and 1975 to 1985, respectively. During these years, more than 70% of all deaths were studied by autopsy in Trieste.

Fasting plasma caffeine level in cirrhotic patients: Relation to plasma levels of catecholamines and renin activity

Mayumi Hasegawa, Sadako Yamada, Chisato Hirayama – 1 December 1989 – Fasting plasma caffeine concentrations, plasma levels of catecholamines and plasma renin activity were measured in patients with cirrhosis and control patients without hepatic dysfunction. A careful dietary history showed no significant difference in caffeine consumption (mean ± S.E.) among 46 cirrhotics (86 ± 7 mg per day) vs. 34 control patients (91 ± 8 mg per day).

Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: A placebo‐controlled clinical trial

Jaime Bosch, Roberto J. Groszmann, Joan C. García‐Pagán, Josep Terés, Guadalupe García‐Tsao, Miquel Navasa, Antoni Mas, Joan Rodés – 1 December 1989 – The aim of this study was to evaluate, using a doubleblind technique, the efficacy of the association of transdermal nitroglycerin to vasopressin infusion for the treatment of variceal bleeding.

A multicenter, randomized, double‐blind trial of somatostatin in the management of acute hemorrhage from esophageal varices

Jorge E. Valenzuela, Timothy Schubert, M. Ronald Fogel, Richard M. Strong, Joel Levine, Peter R. Mills, Thomas L. Fabry, Linda W. Taylor, Harold O. Conn, James T. Posillico, A Multicenter Study Group – 1 December 1989 – A prospective, randomized, placebo‐controlled, double‐blind, multicenter clinical trial of intravenous somatostatin (Stilamin®; Serono Laboratories, Inc., Randolph, MA) was performed in 102 patients with actively bleeding esophageal varices from August, 1985, to November, 1986.

The rat liver microcirculation in alcohol‐induced hepatomegaly

Ricardo Mastaï, P.‐Michel Huet, Antoine Brault, Jocelyne Belgiorno – 1 December 1989 – It has been suggested that hepatocyte enlargement can lead to compression of the extracellular space (sinusoidal and interstitial) and induce portal hypertension. However, this hypothesis has never been tested by measuring the vascular and extravascular spaces in the intact liver. The aim of the present study was to investigate the effects of chronic alcohol intake on the hepatic microcirculation using Goresky's multiple‐indicator dilution technique in the isolated perfused rat liver.

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