1 March 1989

Alexander L. Gerbes, Heinrich Wernze, Rainer M. Arendt, Angelika Riedel, Tilman Sauerbruch, Gustav Paumgartner – 1 March 1989 – The role of the atrial natriuretic factor and of the main counteracting sodium‐retaining principle, the renin‐aldosterone system, in acute volume regulation of cirrhosis of the liver has been investigated. Central volume stimulation was achieved in 21 patients with cirrhosis, 11 without and 10 with ascites, and 25 healthy controls by 1‐hr head‐out water immersion.

Bruce R. Bacon, Robert S. Britton, Rosemary O'Neill – 1 March 1989 – Peroxidative decomposition of organelle membrane phospholipids with subsequent organelle dysfunction is a postulated mechanism of liver cell injury in parenchymal iron overload. We studied the effects of different α‐tocopherol concentrations on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload.

Sheri M. Krams, Charles D. Surh, Ross L. Coppel, Aftab Ansari, Boris Ruebner, M. Eric Gershwin – 1 March 1989 – The availability of recombinant mitochondrial autoantigens may permit the experimental study of the pathophysiology of primary biliary cirrhosis. Previously, we demonstrated that high‐titer antibodies to the 74 kD mitochondrial autoantigen dihydrolipoamide acetyltransferase could be generated when BALB/c mice were immunized with purified recombinant protein.

Dale C. Snover, Sally Weisdorf, Joseph Bloomer, Philip McGlave, Daniel Weisdorf – 1 March 1989 – Liver disease in the early period following bone marrow transplantation may be due to a number of causes, including pretransplant cytoreduction with chemotherapy and irradiation. Although the relationship of veno‐occlusive disease to these agents has been well established, another process, nodular regenerative hyperplasia, may also occur.

Marc L. Berger, Rolland C. Reynolds, Herbert K. Hagler, Dennis Bellotto, Dorabeth Parsons, Kevin J. Mulligan, L. Maximilian Buja – 1 February 1989 – Examination of anoxic isolated hepatocytes by light and electron microscopy indicated that initial morphologic changes were largely localized to the periphery of the cells. This early phase consisted of surface bleb formation but was not accompanied by alterations in parameters of plasma membrane integrity (leakage of cellular enzymes, exclusion of trypan blue).

Christopher K. Daniels, Douglas L. Schmucker, Albert L. Jones – 1 February 1989 – In the rat, asialoorosomucoid and rat dimeric immunoglobulin A are both taken up by hepatocytes via receptor‐mediated endocytosis. The fate of these two proteins, however, differs significantly. Rat dimeric IgA is taken up into smooth vesicles, transported to the bile canaliculus and secreted intact into the bile, whereas asialoglycoproteins are internalized via coated vesicles and transported to lysosomes for degradation.

Glorgina Mieli‐Vergani, Ava Lobo‐Yeo, Barbara M. McFarlane, Ian G. McFarlane, Alex P. Mowat, Diego Vergani – 1 February 1989 – Children with primary sclerosing cholangitis or autoimmune chronic active hepatitis have similar high levels of immunoglobulin G and non‐organ‐specific autoantibodies and may have similar histological features.

Marie V. St‐Pierre, Andreas J. Schwab, Carl A. Goresky, Wai‐Fong Lee, K. Sandy Pang – 1 February 1989 – The technique of normal and retrograde rat liver perfusion has been widely used to probe zonal differences in drug‐metabolizing activities. The validity of this approach mandates the same tissue spaces being accessed by substrates during both normal and retrograde perfusions. Using the multiple‐indicator dilution technique, we presently examine the extent to which retrograde perfusion alters the spaces accessible to noneliminated references.

Hilary A. Wynne, Lance H. Cope, Elaine Mutch, Michael D. Rawlins, Kenneth W. Woodhouse, Oliver F. W. James – 1 February 1989 – The aim of this study was to determine the effect of aging upon liver volume and apparent liver blood flow in healthy man. Sixty‐five subjects between 24 and 91 years of age were recruited. Liver volume was quantitated by a gray scale B ultrasound scan method. Apparent liver blood flow was determined from the plasma clearance of indocyanine green, based on an assumption of no change in hepatic extraction of the dye with age.