Philip J. Snodgrass – 1 March 1989 – We produced moderately severe, inactive micronodular cirrhosis in rats using CCl4 and measured the urea cycle enzyme activities in liver after feeding a 15% casein diet for 1 week and again after a 60% casein diet for 1 week. There was no deficiency of any of the five urea cycle enzymes in cirrhotic livers of rats pair‐fed the 15% casein diet. Argininosuccinate synthetase and carbamyl phosphate synthetase activities were lower than in non‐pair‐fed controls by some baselines.

Toshiji Saibara, Saburo Onishi, Hiroshi Sakaeda, Yasutake Yamamoto – 1 March 1989 – Lymphokine‐activated killer activity and natural killer activity in hepatocellular carcinoma patients were assessed. Maximum lymphokine‐activated killer activity was induced at 3 to 5 days of incubation, and lymphokine‐activated killer activity tended to increase in a manner dose dependent of recombinant interleukin‐2. However, the maximum increase of lymphokine‐activated killer activity in hepatocellular carcinoma was not as high as that of normal subjects or liver cirrhosis patients.

Melchor Hoyos, José V. Sarrión, Teresa Pérez‐Castellanos, Martín Prieto, María L. Marty, Vicente Garrigues, Joaquín Berenguer – 1 March 1989 – The relationship between donor status for antibody to hepatitis B core antigen and the occurrence of non‐A, non‐B posttransfusion hepatitis in the recipient was prospectively studied in 112 patients undergoing open‐heart surgery who were followed for 6.5 months after surgery.

Richard Moreau, Samuel S. Lee, Antoine Hadengue, Yves Ozier, Christian Sicot, Didier Lebrec – 1 March 1989 – To elucidate the relationship between oxygen transport and uptake in cirrhosis, we studied the effects of three vasoactive drugs that change O2 transport. Systemic hemodynamics, blood gases and lactate concentration were measured in patients with alcoholic cirrhosis before and after intravenous dobutamine, propranolol and nitroglycerin. Nine patients received successively dobutamine and then propranolol. Ten patients received nitroglycerin.

Owen Epstein – 1 March 1989

Ernest Urban, Vincent J. Dindzans, David H. Van Thiel – 1 March 1989 – This is a report of six patients with cirrhosis of the liver in whom primary hyperparathyroidism occurred due to a solitary parathyroid adenoma 3 months to 9 years after undergoing emergency portacaval shunt for hemorrhage from esophageal varices. The presenting symptoms in all six patients were weakness and bone pain. Three patients had a bone fracture after insignificant trauma, one and probably two passed kidney stones, and a duodenal ulcer developed in two.

Dwain L. Thiele – 1 March 1989

Georg A. Mathis, Sandra A. Walls, Paul D'Amico, Thomas F. Gengo, Alphonse E. Sirica – 1 March 1989 – An extensive bile ductular cell hyperplasia with the formation of well‐differentiated bile ductules is the most prominent feature of rat liver at 6 to 15 weeks after bile duct ligation. We have improved our previous cell isolation procedure and are now routinely able to obtain from such livers high yields of viable bile ductular epithelial cells.

Tse‐Ling Fong, Evangelos A. Akriviadis, Bruce A. Runyon, Telfer B. Reynolds – 1 March 1989 – The purposes of this study were (a) to measure serially ascitic fluid polymorphonuclear cell response in treated spontaneous bacterial peritonitis and (b) to determine whether an ascitic fluid polymorphonuclear cell count of less than 250 per mm3 on serial paracenteses was a satisfactory endpoint for antibiotic therapy.

Craig J. McClain, Donald A. Cohen – 1 March 1989 – Tumor necrosis factor is a cytokine that mediates many of the biologic actions of endotoxin. Recent studies have shown that tumor necrosis factor administration may cause liver injury and that tumor necrosis factor may mediate the lethality of the hepatotoxin galactosamine. One of the most potent inducers of tumor necrosis factor production is endotoxin.