Safaa El Meneza, G. Richard Olds, Thomas F. Kresina, Adel A. F. Mahmoud – 1 January 1989 – Hepatic fibrosis is the major clinical sequela of infection with the helminth Schistosoma mansoni. However, little is known regarding its dynamics and regulation in schistosomiasis. The present study presents the dynamics of deposition and resorption of two major extracellular matrix components of fibrosis, glycosaminoglycans and collagens, during the course of experimental S. mansoni infection.

Brian J. McMahon, William L. Heyward, David W. Templin, David Clement, Anne P. Lanier – 1 January 1989 – We analyzed the demographic, clinical, laboratory and histologic features of 13 patients who were diagnosed as having polyarteritis nodosa associated with hepatitis B virus infection over a 12‐year period, 1974 to 1985. All 13 patients were Yupik Eskimos and resided in southwest Alaska, an area hyperendemic for hepatitis B virus infection. The annual incidence of hepatitis B virus‐associated polyarteritis nodosa for this population is 7.7 cases per 100,000 population.

1 January 1989

1 January 1989

Elsa Springolo, Michael C. Kew, Jan Esser, Margaretha Beyers, Jan D. Conradie, Joseph Levin – 1 January 1989 – The purpose of this study was to investigate the use of a radiolabeled mouse monoclonal antibody (and its F(ab′)2 fragment) against α‐fetoprotein in the scinti‐graphic diagnosis of hepatocellular carcinoma. Twenty‐six southern African Blacks and one Caucasian with hepatocellular carcinoma and four patients with other malignant tumors of the liver were studied.

Ulrich Marti, Susan Jo Burwen, Albert L. Jones – 1 January 1989

Shakuntala Krishnamurthy, Gerbail T. Krishnamurthy – 1 January 1989 – Technetium‐99m‐labeled iminodiacetic acid analogs are a new class of organic anions, taken up and secreted by hepatocyte into hepatic bile by a carrier‐mediated organic anion pathway. They provide a new dimension in the assessment of pathophysiology and morphology of the hepatobiliary system. The amount of uptake and the rapidity of its elimination from the liver is dependent upon the structural configuration of the agent as well as the functional integrity of the hepatocyte and the patency of the biliary system.

M. S. Lennard – 1 January 1989 – Metoprolol is as widely used beta‐adrenoreceptor antagonist. There is no report of hepatitis involving this drug as well as other beta‐adrenoreceptor antagonists. Metoprolol is metabolized by three major oxidation pathways. Two of them, Odealkylation and alpha‐hydroxylation, undergo genetically controlled polymorphisms correlated with that of debrisoquine oxidation.

Cyrus R. Kapadia – 1 January 1989

Charles D. Surh, Dean J. Danner, Aftab Ahmed, Ross L. Coppel, Ian R. Mackay, E. Rolland Dickson, M. Eric Gershwin – 1 January 1989 – Antimitochondrial autoantibodies recognizing 68 to 74 and 50 to 52 kD inner membrane mitochondrial antigens are characteristically present in sera of patients with primary biliary cirrhosis. The biochemical identification of the antigens, however, has remained elusive. We report herein that the 52 kD antigen is the dihydrolipoamide acyltransferase of the branched‐chain α‐keto acid dehydrogenase complex.