Vitamin E deficiency in primary biliary cirrhosis: Gastrointestinal malabsorption, frequency and relationship to other lipid‐soluble vitamins

Santiago J. Muñoz, James E. Heubi, William F. Balistreri, Willis C. Maddrey – 1 April 1989 – In contrast to deficiencies of vitamins A, D and K, little is known of the prevalence, clinical manifestations and mechanisms of vitamin E deficiency in adult patients with cholestasis. We measured serum vitamin E levels in 45 patients with primary biliary cirrhosis, 20 with primary sclerosing cholangitis, 9 with cryptogenic cirrhosis and 12 with alcoholic cirrhosis.

Experimental systems for the study of hepadnavirus and hepatitis delta virus infections

William S. Mason, John M. Taylor – 1 April 1989 – The past decade has seen a dramatic increase in the number of approaches available for the study of hepadnavirus and hepatitis delta virus infections. In this review, we have summarized the recent applications of these approaches to the study of virus replication, tissue specificity, liver injury and hepatocellular carcinogenesis.

The effect of estrogen and tamoxifen on hepatocyte proliferation in Vivo and in Vitro

Antonio Francavilla, Lorenzo Polimeno, Alfredo Dileo, Michele Barone, Peter Ove, Mona Coetzee, Patricia Eagon, Leonard Makowka, Giovanni Ambrosino, Vincenzo Mazzaferro, Thomas E. Starzl – 1 April 1989 – We have previously shown that changes in estrogen‐hepatocyte interaction occur during liver regeneration. Following 70% hepatectomy, estrogen levels in the blood were elevated, the number of estrogen receptors in the liver was increased and there was an active translocation of estrogen receptors from the cytosol to the nucleus.

Changes in liver and spleen volume in alcoholic liver fibrosis of man

Kazuo Tarao, Hiroshi Hoshino, Ikuko Motohashi, Kazuto Iimori, Setsuo Tamai, Yoshihiko Ito, Seiichi Takagi, Yubo Oikawa, Shiro Unayama, Takuya Fujiwara, Kunio Odagiri, Toshio Ikeda, Kazuhiro Hayashi, Akira Sakurai, Toshiyuki Uchikoshi – 1 April 1989 – Alcoholic liver fibrosis is a relatively common form of alcoholic liver disease in Japan. It is regarded by some investigators as a prodromal stage of alcoholic liver cirrhosis, but little is known about the volumes of the liver and spleen in this disease state.

Vitamin B6 repletion in cirrhosis with oral pyridoxine: Failure to improve amino acid metabolism

J. Michael Henderson, Steven S. Scott, Alfred H. Merrill, Bettye Hollins, Michael H. Kutner – 1 April 1989 – This study evaluated the effect of daily oral pyridoxine supplementation in patients with cirrhosis. Eight subjects were treated with 25 mg of pyridoxine for 28 days. Before and after the supplementation period, B6 status was assessed by measuring fasting plasma vitamer levels and response to a 25 mg oral pyridoxine load. In addition, a 24‐hr urine collection was analyzed during each load study for B6 metabolites.

Gentamicin nephrotoxicity in extrahepatic cholestasis: Modulation by dietary calcium

Nimish Vakil, Ali Abu‐Alfa, Salim K. Mujais – 1 April 1989 – The present study was designed to test the hypothesis that the presence of a specific hepatobiliary disease, namely common bile duct obstruction, in the absence of other risk factors will exacerbate gentamicin nephrotoxicity. Furthermore, since bile duct ligation decreases urinary calcium excretion, we studied the role of calcium supplementation in the prevention of gentamicin nephrotoxicity in this model. Male Sprague‐Dawley rats were allocated to sham groups and common bile duct ligation groups.

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