Gaetano Cairo, Luisa Schiaffonati, Emilia Rappocciolo, Lorenza Tacchini, Aldo Bernelli‐Zazzera – 1 May 1989 – The levels of expression of some genes of the HSP 70 family have been assessed in rat liver and in a series of transplantable hepatomas with different growth rates, subjected to heat shock in vivo. For this purpose, the mRNAs for the constitutive cognate HSC 73, the heat‐inducible HSP 70 and the glucose‐regulated GRP 78 have been analyzed by: (i) translation in reticulocyte lysates; (ii) hybrid‐selected translation, and (iii) Northern blot analysis.

Jesús Prieto, Alberto Castilla, María‐Luisa Subirá, Manuel Serrano, Susana Morte, María‐pilar Civeira – 1 May 1989 – Monocytes play an important role in the initiation and regulation of the antiviral immune response. These cells have a dense framework of intermediate filaments composed of vimentin monomers.

J. R. Thornton, M. S. Losowsky, Robert W. Schrier – 1 May 1989

William R. Brown, Thomas M. Kloppel – 1 May 1989 – Secretory immunoglobulin A is the characteristic and predominant immunoglobulin of the mucosal immune system; it participates in immunological protection at the level of mucous membrane surfaces. During the past 10 to 15 years, a great deal of experimental and clinical evidence has shown that the liver is very much involved in the sIgA system.

Nancy Bach, Fenton Schaffner, Barbara Kapelman – 1 May 1989 – Sexual behavior in women with liver disease was examined in 150 women to determine whether liver disease influenced sexual desire, frequency or performance. The average age of women studied was 53 years (range: 26 to 76 years), and a wide variety of liver diseases were represented. Sexual desire was reduced in 33%. Difficulty in becoming sexually aroused was noted by 18%. Orgasm during intercourse was not experienced by 25%. The frequency of sexual intercourse decreased since onset of disease in 27%.

Giorgio Annoni, Massimo Colombo, Maria Cristina Cantaluppi, Boutros Khlat, Pietro Lampertico, Marcos Rojkind – 1 May 1989 – The diagnosis of alcoholic hepatitis is difficult to establish by conventional clinical and laboratory methods, and a firm diagnosis relies on liver histology. Since there are severe limitations in following patients with repeated liver biopsies, noninvasive procedures are needed to assess the presence of alcoholic hepatitis in chronic alcohol abusers.

Lance R. Pohl – 1 May 1989

Brian E. Huber, Carole A. Heilman, Snorril S. Thorgeirsson – 1 May 1989 – The development of chemically induced hepatocellular carcinoma in the rat proceeds through a series of premalignant changes that may ultimately progress to a primary malignant tumor. Using the selection technique based on diminished binding of preneoplasic hepatocytes to tissue culture plates precoated with asialofetuin, we have isolated poly(A+)RNA from early preneoplastic foci as well as preneoplastic persistent nodules and primary hepatocellular carcinoma induced by the Solt‐Farber protocol in the Fischer rat.

Shujiro Takase, Akira Takada, Minoru Yasuhara, Mikihiro Tsutsumi – 1 May 1989 – Hepatic aldehyde dehydrogenase isozyme activity was measured in 51 patients with various types of liver diseases, including 24 patients with alcoholic liver disease, to elucidate the relationship between hepatic aldehyde dehydrogenase activity and liver disease, especially alcoholic liver disease. The levels of low‐Km and total aldehyde dehydrogenase activity in the liver decreased both in alcoholic and nonalcoholic liver disease patients, who showed an isoelectric focusing pattern of the usual type.

Rudi Schmid, Steven Schenker – 1 May 1989