Caroline A. Riely – 1 July 1989

Wilfried Bursch, Hendryk S. Taper, Marie P. Somer, Stefan Meyer, Barbara Putz, Rolf Schulte‐Hermann – 1 June 1989 – In the present study, it was investigated whether the prostacyclin derivative Iloprost would protect hepatocytes against CCl4‐induced liver injury and which mechanism(s) of hepatocellular pathogenesis might be affected by it. Rats were treated with a single oral dose of CC14 (2 ml per kg); Iloprost was infused continuously from 2 to 4 hr before intoxication until killing. The following results were obtained.

Olivier Chazouillères, François Ballet, Yves Chrétien, Philippe Marteau, Colette Rey, Dominique Maillard, Raoul Poupon – 1 June 1989 – The effects of two vasodilators, papaverine and pentoxifylline (a methylxanthine derivative), on liver function after 19 hr hypothermic preservation were investigated. Hypothermic preservation was performed according to the standard technique, and liver hemodynamics and function were studied during 70 min immediately after reperfusion in an isolated perfused rat liver system. No significant changes occurred after hypothermic storage for 5 hr.

Richard A. Galbraith, Attallah Kappas – 1 June 1989 – Tin‐mesoporphyrin shares many of the properties of its parent compound, tin‐protoporphyrin. These include competitive inhibition of heme oxygenase, amelioration of jaundice and suppression of chemically induced hepatic porphyria. Tin‐mesoporphyrin is cleared from the plasma of normal subjects with dose‐dependent pharmacokinetics (T1/2 = 3.8 hr following i.v. administration of 1 μmole per kg body weight), and small amounts (<1% of administered dose) are excreted into the urine and feces.

Atilla Ertan – 1 June 1989

William G. M. Hardison, Philip J. Lowe, Miya Shanahan – 1 June 1989 – The permeability pathway into the biliary tree for small inert molecules exhibits a charge selectivity. Using a method which distinguishes trans‐ from paracellular access, we have examined the charge selectivity of biliary access pathways for the 40‐kD protein horseradish peroxidase (pI 7.5), which was derivatized to strongly anionic (pI < 3.5) and strongly cationic (pI > 9.5) isoenzymes.

Torben Jørgensen – 1 June 1989 – To date, it has never been established which symptoms are specifically caused by stones in the gallbladder. To examine this issue, the relationship between occurrence of gallstone disease diagnosed by ultrasonography and complaints about abdominal pain and discomfort was assessed in a random sample comprising 4,581 males and females, of whom 3,608 (79%) took part in the investigation.

Masao Arai, Shigeo Nakano, Fumio Okuno, Yoshiaki Hirano, Kazufumi Sujita, Toshiji Kobayashi, Hiromasa Ishii, Masaharu Tsuchiya – 1 June 1989 – The present experiments were designed to study the effect of chronic ethanol consumption on endotoxin toxicity. The intravenous injection of endotoxin produced a more pronounced increase of serum AST and ALT activities in chronic ethanol‐fed rats, when compared to controls.

David Kravetz, Jaime Bosch, Maite Arderiu, M. Pilar Pizcueta, Juan Rodés – 1 June 1989 – The present study investigated whether, in rats with portal hypertension due to cirrhosis of the liver induced by carbon tetrachloride, blood volume restitution following a hemorrhage produces an increase of portal pressure beyond control values, as observed in rats with prehepatic portal hypertension.

William F. Balistreri – 1 June 1989