Autoradiographic analysis of GABA‐benzodiazepine receptors in an animal model of acute hepatic encephalopathy

Martin Rössle, Jürgen Deckert, E. Anthony Jones – 1 August 1989 – To complement analogous studies using conventional ligand‐membrane binding assays, the densities of γ‐aminobutyric acid and benzodiazepine receptors in the brain have been assessed using an autoradiographic technique in an animal model of hepatic encephalopathy. Hepatic encephalopathy due to fulminant hepatic failure was induced in rabbits by the intravenous injection of galactosamine.

Serial antipyrine clearance studies detect altered hepatic metabolic function during spontaneous and interferon‐induced changes in chronic hepatitis B disease activity

Stephen J. Williams, Geoffrey C. Farrell – 1 August 1989 – The present study was performed to establish whether sequential determinations of antipyrine clearance, using a simplified two‐point test, are sensitive and specific indicators of changes in chronic hepatitis B disease activity. Sixteen patients were studied on four or more occasions during 18 to 30 months. Eleven patients were treated with recombinant human α‐interferon (2.5, 5.0 or 10 × 106 per m2, intramuscularly, three times per week, for 24 weeks), and five patients were untreated controls.

Enhanced acetaminophen toxicity in rats with bilirubin glucuronyl transferase deficiency

Sonia M. F. de Morais, Peter G. Wells – 1 August 1989 – Glucuronidation is the major pathway for elimination of acetaminophen, diverting it from the toxifying pathway catalyzed by cytochromes P‐450. A genetic deficiency in bilirubin UDP‐glucuronyl transferase may predispose humans and animals to the toxicity of drugs that are extensively glucuronidated, if other glucuronyl transferase isoenzymes are concurrently deficient. Homozygous and heterozygous Gunn rats are, respectively, severely and moderately deficient in glucuronyl transferase.

Increased bioavailability of enzymes of eicosanoid synthesis in hepatic and extrahepatic tissues after portacaval shunting

Matthias Goerig, Heinrich Wernze, Burkhard Kommerell, Martin Grün – 1 August 1989 – Metabolites of arachidonic acid have been attributed to severe circulatory, metabolic and hormonal alterations in patients with chronic liver disease. In order to study changes of the tissue‐specific availability of enzymes of eicosanoid synthesis, we used portacavalshunted rats, as this model exhibits many clinical and biochemical similarities to patients suffering from cirrhosis of the liver.

Prolonged duck hepatitis B virus replication in duck hepatocytes cocultivated with rat epithelial cells: A useful system for antiviral testing

Isabelle Fourel, Philippe Gripon, Oliver Hantz, Lucyna Cova, Véronique Lambert, Chantal Jacquet, Kyoichi Watanabe, Jack Fox, Christiane Guillouzo, Christian Trepo – 1 August 1989 – Duck cultured hepatocytes from Pekin ducks naturally infected by duck hepatitis B virus can remain functional twice longer if a coculture system with rat liver epithelial cells is used instead of ordinary primary culture.

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