J. Michael Tredger, Roger Williams – 1 September 1989 – In patients with liver disease, the synthesis of drug‐binding proteins may be impaired. After liver transplantation, levels of drug‐binding proteins are unknown. Consequently, concentrations of albumin and α‐acid glycoprotein (AAG) were measured in stable patients after liver transplantation. Albumin levels were decreased from normal (4.5 ± 3 gm per dl) in patients with liver disease before (3.4 ± 0.7) and after transplantation (3.4 ± 0.8).

1 September 1989

Stanislas Pol, Frédéric Dubois, Philippe Roingeard, Linda Zignego, Chantal Housset, Christian Brechot, Alain Goudeau, Pierre Berthelot – 1 September 1989 – The prevalence and serological features of hepatitis delta virus infections were studied in a French population of chronic, non‐drug addict, hepatitis B surface antigen carriers: 42 male homosexual patients were compared to 30 nonhomosexuals (20 who evidently had not been exposed to any of the usual hepatitis B virus‐hepatitis delta virus risk factors and 10 hemodialyzed patients or kidney allograft recipients).

Jérǒme Guéchot, Nicolas Peigney, François Ballet, Michel Vaubourdolle, Jacqueline Giboudeau, Raoul Poupon – 1 September 1989 – Certain evidence suggests androgen dependence of hepatocellular carcinoma in cirrhotic patients. Consequently, it was postulated that antiandrogen therapy might be effective in the treatment of hepatocellular carcinoma. D‐Tryptophan‐6‐luteinizing hormone‐releasing hormone is a potent agonist analog of luteinizing hormone‐releasing hormone which, when chronically administered, inhibits the pituitary gonadal axis and testicular androgen secretion in man.

Rex J. Polson, David Westaby, Alexander E. S. Gimson, Peter C. Hayes, Anthony J. Stellon, Karen Hayllar, Roger Williams – 1 September 1989 – One hundred eighty patients with variceal bleeding and treated by long‐term sclerotherapy were randomized into a prospective randomized controlled clinical trial to assess the efficacy of sucralfate in reducing the frequency of rebleeding from esophageal ulceration prior to variceal obliteration.

Alastair Forbes, Graeme J. M. Alexander, John G. O'Grady, Richard Keays, Richard Gullan, Sheila Dawling, Roger Williams – 1 September 1989 – Intracranial hypertension complicating fulminant hepatic failure has a mortality in excess of 90% in the presence of renal failure if not rapidly responsive to mannitol and ultrafiltration. Based on data which suggest that barbiturates can be of value in controlling the intracranial hypertension of head injury, intravenous thiopental was assessed in 13 patients with fulminant hepatic failure.

Craig E. Thomas, Donald J. Reed – 1 September 1989

Tasmin A. Knox, Marshal M. Kaplan – 1 September 1989 – In a prospective study of 33 adults with portal vein thrombosis unrelated to a liver tumor, we have assessed the prevalence of primary myeloproliferative disorders using conventional criteria and cultures of bone marrow progenitor cells. A primary myeloproliferative disorder was documented in 14 patients investigated at the time of recognition of portal vein thrombosis.

Saburo Onishi, Toshiji Saibara, Masanao Fujikawa, Hiroshi Sakaeda, Yasushi Matsuura, Yoichi Matsunaga, Yasutake Yamamoto – 1 September 1989 – Ten patients with hepatocellular carcinoma, three of whom had pulmonary metastasis, were treated with adoptive immunotherapy using autologous lymphokine‐activated killer cells plus recombinant interleukin 2.

Giorgio Saracco, Giuseppe Mazzella, Floriano Rosina, Claudio Cancellieri, Valter Lattore, Enzo Raise, Giuseppe Rocca, Laura Giorda, Giorgio Verme, Giovanni Gasbarrini, Luigi Barbara, Ferruccio Bonino, Mario Rizzetto, Enrico Roda – 1 September 1989 – Sixty‐four heterosexual Italian carriers of HBsAg with chronic HBeAg and hepatitis B virus DNA‐positive hepatitis were assigned randomly either to receive human lymphoblastoid interferon (injections of 5 million units per m2 three times per week for 6 months) or to serve as untreated controls.