Key developments in gastroenterology. Edited by P. R. Salmon, 194 pp. New York: Alan R. Liss, Inc., 1988. $54.75
Naurang M. Agrawal – 1 October 1989
Primary biliary cirrhosis: Lymphocyte subsets and function in a time frame
F. Konikoff, M. Pecht, E. Theodor, Y. Shoenfeld, Keith D. Lindor – 1 October 1989
Defective immunoregulation in primary biliary cirrhosis: CD4+, Leu–8+ T cells have abnormal activation and suppressor function in vitro
Takeaki Suou, Maria P. Civeira, Marjorie E. Kanof, Ricardo Moreno‐Otero, E. Anthony Jones, Stephen P. James – 1 October 1989 – To determine whether abnormalities of lymphocyte function in primary biliary cirrhosis are due to altered function of immunoregulatory T cell subpopulations, phenotypic and functional characteristics of CD4+ T cells were examined. The proportion of CD4+ T cells expressing the Leu‐8 and CD45R antigens was normal in patients with primary biliary cirrhosis.
Bile acids inhibit endotoxin‐induced release of tumor necrosis factor by monocytes: An in Vitro study
Jan Willem Greve, Dirk J. Gouma, Wim A. Buurman – 1 October 1989 – Endotoxins play an important role in the pathogenesis of complications of surgery in obstructive jaundice. Preoperative treatment with orally administered deoxycholic acid prevented endotoxin‐related complications, such as renal malfunction. Other bile acids, however, were less effective, and the mechanism of action is not known.
Aplastic anemia after liver transplantation for fulminant viral hepatitis: Black boX or bag of worms?
Jerome B. Zeldis – 1 October 1989 – Aplastic anemia developed in 9 of 32 patients (28 percent) undergoing orthotopic liver transplantation for acute non‐A, non‐B hepatitis, at one to seven weeks after the procedure. No patient previously had evidence of hematologic dysfunction or conditions known to be associated with aplastic anemia.
Nitrous oxide interferes with the aminopyrine breath test
Donald D. Koblin, Rosemary Hickman – 1 October 1989
Program of the Postgraduate Course
1 October 1989
A pilot, double‐blind, controlled 1‐year trial of prednisolone treatment in primary biliary cirrhosis: Hepatic improvement but greater bone loss
Harriet C. Mitchison, Margaret F. Bassendine, Archie J. Malcolm, Alex J. Watson, Christopher O. Record, Oliver F. W. James – 1 October 1989 – A randomized, double‐blind, 1‐year pilot study of prednisolone treatment for primary biliary cirrhosis was undertaken. Nineteen patients received 30 mg prednisolone per day initially, with a maintenance dose of 10 mg per day. Seventeen patients received placebo. The groups were matched for age, menopausal status, hepatic histological stage and bilirubin.
Taurocholate transport by basolateral plasma membrane vesicles isolated from human liver
Donald A. Novak, Frederick C. Ryckman, Frederick J. Suchy – 1 October 1989 – Transport of taurocholate into the hepatocyte against unfavorable chemical and electrical gradients occurs via a sodium‐dependent, carrier‐mediated transport system. Although this cotransporter has been characterized in the rodent, it has not been demonstrated in man. Therefore, we utilized human liver, obtained via multiorgan donation but not used for transplantation, to prepare basolateral (sinusoidal) liver plasma membrane vesicles by a Percoll gradient method.