Jan Willem Greve, Dirk J. Gouma, Wim A. Buurman – 1 October 1989 – Endotoxins play an important role in the pathogenesis of complications of surgery in obstructive jaundice. Preoperative treatment with orally administered deoxycholic acid prevented endotoxin‐related complications, such as renal malfunction. Other bile acids, however, were less effective, and the mechanism of action is not known.

Takeaki Suou, Maria P. Civeira, Marjorie E. Kanof, Ricardo Moreno‐Otero, E. Anthony Jones, Stephen P. James – 1 October 1989 – To determine whether abnormalities of lymphocyte function in primary biliary cirrhosis are due to altered function of immunoregulatory T cell subpopulations, phenotypic and functional characteristics of CD4+ T cells were examined. The proportion of CD4+ T cells expressing the Leu‐8 and CD45R antigens was normal in patients with primary biliary cirrhosis.

F. Konikoff, M. Pecht, E. Theodor, Y. Shoenfeld, Keith D. Lindor – 1 October 1989

James Gilbert – 1 October 1989

Naurang M. Agrawal – 1 October 1989

Dominique Roulot, Alain Braillon, Christophe Gaudin, Yves Ozier, Catherine Girod, Didier Lebrec – 1 October 1989 – The effects of clonidine on portal pressure and splanchnic blood flow were studied in conscious rats with sinusoidal portal hypertension due to cirrhosis induced by bile duct ligation. In cirrhotic and sham‐operated rats, clonidine (20 μg per kg body weight, intravenously) significantly reduced portal, pressure from 19.0 ± 0.6 to 14.5 ± 1.0 mmHg and from 9.8 ± 0.9 to 7.3 ± 0.5 mmHg, respectively. No significant change in systemic hemodynamics was observed.

Mikihiro Tsutsumi, Jerome M. Lasker, Masanori Shimizu, Alan S. Rosman, Charles S. Lieber – 1 October 1989 – Perivenular hepatocytes are the first cells within the liver lobule to display signs of toxicity following long‐term alcohol use. In an attempt to explain this phenomenon, we have examined the hepatic intralobular distribution in rats and man of P450IIE1, a P‐450 isozyme that not only oxidizes ethanol but is also inducible by this agent.

Burton Combes – 1 October 1989

Yutaka Sasaki, Norio Hayashi, Yasuhiro Morita, Toshifumi Ito, Akinori Kasahara, Hideyuki Fusamoto, Nobuhiro Sato, Masaya Tohyama, Takenobu Kamada – 1 October 1989 – Expression of the c‐Ha‐ras proto‐oncogene is specifically enhanced during liver regeneration, in parallel with increased DNA replication, which suggests that c‐Ha‐ras may play a role in the control of regeneration. In this study, an in situ hybridization technique was applied for analysis of expression of the c‐Ha‐ras gene at the cellular level during liver regeneration induced by CCl4 administration.

1 October 1989