Richard A. Galbraith, Attallah Kappas – 1 June 1989 – Tin‐mesoporphyrin shares many of the properties of its parent compound, tin‐protoporphyrin. These include competitive inhibition of heme oxygenase, amelioration of jaundice and suppression of chemically induced hepatic porphyria. Tin‐mesoporphyrin is cleared from the plasma of normal subjects with dose‐dependent pharmacokinetics (T1/2 = 3.8 hr following i.v. administration of 1 μmole per kg body weight), and small amounts (<1% of administered dose) are excreted into the urine and feces.

Olivier Chazouillères, François Ballet, Yves Chrétien, Philippe Marteau, Colette Rey, Dominique Maillard, Raoul Poupon – 1 June 1989 – The effects of two vasodilators, papaverine and pentoxifylline (a methylxanthine derivative), on liver function after 19 hr hypothermic preservation were investigated. Hypothermic preservation was performed according to the standard technique, and liver hemodynamics and function were studied during 70 min immediately after reperfusion in an isolated perfused rat liver system. No significant changes occurred after hypothermic storage for 5 hr.

Wilfried Bursch, Hendryk S. Taper, Marie P. Somer, Stefan Meyer, Barbara Putz, Rolf Schulte‐Hermann – 1 June 1989 – In the present study, it was investigated whether the prostacyclin derivative Iloprost would protect hepatocytes against CCl4‐induced liver injury and which mechanism(s) of hepatocellular pathogenesis might be affected by it. Rats were treated with a single oral dose of CC14 (2 ml per kg); Iloprost was infused continuously from 2 to 4 hr before intoxication until killing. The following results were obtained.

Jessica H. Lewis, Franklin A. Bontempo, Sami A. Awad, Yoo Goo Kang, Joseph E. Kiss, Margaret V. Ragni, Joel A. Spero, Thomas E. Starzl – 1 May 1989 – Six intraoperative blood samples were obtained at intervals from each of 100 individuals undergoing their first liver transplants. The patients fell into the following diagnostic categories: postnecrotic cirrhosis 28, primary biliary cirrhosis 20, sclerosing cholangitis 19, miscellaneous diseases 14, carcinoma/neoplasia 12 and fulminant hepatitis 7. Coagulation factor values in the initial (baseline) blood samples varied by patient diagnosis.

Fukuo Kondo, Katsunori Wada, Yoshinobu Nagato, Tohru Nakajima, Yoichiro Kondo, Noboru Hirooka, Masaaki Ebara, Masao Ohto, Kunio Okuda – 1 May 1989 – Nodular hepatic lesions detected in 123 patients with chronic liver diseases were subjected to ultrasonically guided needle biopsy. Of these, 94 cases were diagnosed as hepatocellular carcinoma of a moderately or poorly differentiated type with classical histologic features of hepatocellular carcinoma.

Jacqueline Loeper, Véronique Descatoire, Gilles Amouyal, Philippe Lettéron, Dominique Larrey, Dominique Pessayre – 1 May 1989 – Isaxonine and several other drugs transformed by cytochrome P‐450 into reactive metabolites apparently lead to immunoallergic hepatitis in man. Protein epitopes modified by the covalent binding of the metabolites have been proposed as possible targets for the immune response. The purpose of this work was to determine whether covalently bound metabolites are indeed present on hepatocyte plasma membrane proteins.

James H. Lewis, Richard C. Ranard, Anthony Caruso, Lawrence K. Jackson, Florabel Mullick, Kamal G. Ishak, Leonard B. Seeff, Hyman J. Zimmerman – 1 May 1989 – The prevalence of apparent amiodarone‐related hepatic injury in 104 patients followed prospectively is compared to that reported in the literature. Asymptomatic elevation of serum aminotransferase levels was detected in approximately one‐fourth of the patients, a figure similar to the average of reported cases. The frequency of extrahepatic organ toxicity was increased in patients with elevated levels.

Edward S. Feldman, Bruce R. Bacon – 1 May 1989 – Both human porphyria cutanea tarda and experimental hexachlorobenzene‐induced porphyria are associated with hepatic injury and are potentiated by excess hepatic iron. The mechanisms whereby cellular injury occurs and the synergistic role of iron overload are unknown. In the present experiments, we studied hepatic mitochondrial function and lipid peroxidation in rats with hexachlorobenzene‐induced porphyria in which iron loading was achieved by dietary carbonyl iron supplementation.

Katherine S. Koch, Hyam L. Leffert – 1 May 1989 – Two individuals undergoing orthotopic hepatic transplantation received livers from donors who were on average 10 kg smaller than themselves based on recipient ideal body weight. As a result, the donor livers in these 2 cases were 29%‐59% smaller than would be expected had the donor liver and recipient been matched ideally.

Swan N. Thung – 1 May 1989