Frequency of IgG and IgM autoantibodies to four specific M2 mitochondrial autoantigens in primary biliary cirrhosis

David J. Mutimer, Shelley P. M. Fussey, Stephen J. Yeaman, Peter J. Kelly, Oliver F. W. James, Margaret F. Bassendine – 1 October 1989 – We have previously identified four of the M2 antigens in primary biliary cirrhosis as the E2 components (dihydrolipoamide acyltransferases) of pyruvate dehy‐drogenase complex, branched‐chain 2‐oxo acid dehy‐drogenase complex and 2‐oxoglutarate dehydrogenase complex and the protein X component of pyruvate dehydrogenase complex (approximate molecular masses: 74, 50, 50 and 52 kD, respectively).

Reovirus 3 and neonatal biliary disease: Discussion of divergent results

Rachel Morecki, Joy Glaser – 1 October 1989 – Infection with reovirus 3 (Reo‐3) has been suggested as the cause of extrahepatic biliary atresia and idiopathic neonatal hepatitis but confirmation has been lacking. Therefore we have searched for a specific anti‐Reo‐3 antibody response in the sera of patients with biliary atresia or neonatal hepatitis and for Reo‐3 antigens in their hepatobiliary tissues.

Cellular analysis of c‐Ha‐ras gene expression in rat liver after CCl4 administration

Yutaka Sasaki, Norio Hayashi, Yasuhiro Morita, Toshifumi Ito, Akinori Kasahara, Hideyuki Fusamoto, Nobuhiro Sato, Masaya Tohyama, Takenobu Kamada – 1 October 1989 – Expression of the c‐Ha‐ras proto‐oncogene is specifically enhanced during liver regeneration, in parallel with increased DNA replication, which suggests that c‐Ha‐ras may play a role in the control of regeneration. In this study, an in situ hybridization technique was applied for analysis of expression of the c‐Ha‐ras gene at the cellular level during liver regeneration induced by CCl4 administration.

The intralobular distribution of ethanol‐inducible P450IIE1 in rat and human liver

Mikihiro Tsutsumi, Jerome M. Lasker, Masanori Shimizu, Alan S. Rosman, Charles S. Lieber – 1 October 1989 – Perivenular hepatocytes are the first cells within the liver lobule to display signs of toxicity following long‐term alcohol use. In an attempt to explain this phenomenon, we have examined the hepatic intralobular distribution in rats and man of P450IIE1, a P‐450 isozyme that not only oxidizes ethanol but is also inducible by this agent.

Mechanisms of a clonidine‐induced decrease in portal pressure in normal and cirrhotic conscious rats

Dominique Roulot, Alain Braillon, Christophe Gaudin, Yves Ozier, Catherine Girod, Didier Lebrec – 1 October 1989 – The effects of clonidine on portal pressure and splanchnic blood flow were studied in conscious rats with sinusoidal portal hypertension due to cirrhosis induced by bile duct ligation. In cirrhotic and sham‐operated rats, clonidine (20 μg per kg body weight, intravenously) significantly reduced portal, pressure from 19.0 ± 0.6 to 14.5 ± 1.0 mmHg and from 9.8 ± 0.9 to 7.3 ± 0.5 mmHg, respectively. No significant change in systemic hemodynamics was observed.

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