Subrat K. Panda, Rakesh Datta, Jagjit Kaur, Arie J. Zuckerman, Nabeen C. Nayak – 1 October 1989 – An epidemic of viral hepatitis, serologically characterized as due to non‐A, non‐B hepatitis, occurred in a village of South Delhi, India, in December, 1986, through January, 1987. Water contaminated with fecal matter was the apparent source of infection. Disease‐associated virus‐like particles were detected by immune electron microscopy in the feces of three patients within 5 days of illness.

Ashok K. Batta, Gerald Salen, Renu Arora, Sarah Shefer, G. Stephen Tint, John Abroon, David Eskreis, Seymour Katz – 1 October 1989 – We have compared the effect of ursodeoxycholic acid with placebo on the clinical state, blood liver chemistries and serum and urinary bile acids in four patients with primary biliary cirrhosis. All parameters were evaluated monthly, and bile acid composition was measured by capillary gas‐liquid chromatography.

1 October 1989

Marie‐Jose Ramond, Dominique Valla, Jean‐François Mosnier, Claude Degott, Jacques Bernuau, Bernard Rueff, Jean‐Pierre Benhamou – 1 October 1989 – In 27 patients who had bled from esophagogastric varices, large‐sized and/or actively bleeding gastric varices were endoscopically obturated with the tissue adhesive butyl cyanoacrylate. Active bleeding was stopped in six patients.

Peter R. Galle, Hans‐jürgen Schlicht, Christa Kuhn, Heinz Schaller – 1 October 1989 – Primary duck hepatocytes obtained from Pekin ducks congenitally infected with duck hepatitis B virus were used to monitor expression of viral proteins and replication of viral DNA in cell culture. Duck hepatitis B virus core antigen, duck hepatitis B virus pre‐surface antigen and duck hepatitis B virus DNA were detectable for at least 12 days after cell plating.

Donald A. Novak, Frederick C. Ryckman, Frederick J. Suchy – 1 October 1989 – Transport of taurocholate into the hepatocyte against unfavorable chemical and electrical gradients occurs via a sodium‐dependent, carrier‐mediated transport system. Although this cotransporter has been characterized in the rodent, it has not been demonstrated in man. Therefore, we utilized human liver, obtained via multiorgan donation but not used for transplantation, to prepare basolateral (sinusoidal) liver plasma membrane vesicles by a Percoll gradient method.

Harriet C. Mitchison, Margaret F. Bassendine, Archie J. Malcolm, Alex J. Watson, Christopher O. Record, Oliver F. W. James – 1 October 1989 – A randomized, double‐blind, 1‐year pilot study of prednisolone treatment for primary biliary cirrhosis was undertaken. Nineteen patients received 30 mg prednisolone per day initially, with a maintenance dose of 10 mg per day. Seventeen patients received placebo. The groups were matched for age, menopausal status, hepatic histological stage and bilirubin.

1 October 1989

Donald D. Koblin, Rosemary Hickman – 1 October 1989

Jerome B. Zeldis – 1 October 1989 – Aplastic anemia developed in 9 of 32 patients (28 percent) undergoing orthotopic liver transplantation for acute non‐A, non‐B hepatitis, at one to seven weeks after the procedure. No patient previously had evidence of hematologic dysfunction or conditions known to be associated with aplastic anemia.