Aplastic anemia after liver transplantation for fulminant viral hepatitis: Black boX or bag of worms?

Jerome B. Zeldis – 1 October 1989 – Aplastic anemia developed in 9 of 32 patients (28 percent) undergoing orthotopic liver transplantation for acute non‐A, non‐B hepatitis, at one to seven weeks after the procedure. No patient previously had evidence of hematologic dysfunction or conditions known to be associated with aplastic anemia.

Bile acids inhibit endotoxin‐induced release of tumor necrosis factor by monocytes: An in Vitro study

Jan Willem Greve, Dirk J. Gouma, Wim A. Buurman – 1 October 1989 – Endotoxins play an important role in the pathogenesis of complications of surgery in obstructive jaundice. Preoperative treatment with orally administered deoxycholic acid prevented endotoxin‐related complications, such as renal malfunction. Other bile acids, however, were less effective, and the mechanism of action is not known.

Defective immunoregulation in primary biliary cirrhosis: CD4+, Leu–8+ T cells have abnormal activation and suppressor function in vitro

Takeaki Suou, Maria P. Civeira, Marjorie E. Kanof, Ricardo Moreno‐Otero, E. Anthony Jones, Stephen P. James – 1 October 1989 – To determine whether abnormalities of lymphocyte function in primary biliary cirrhosis are due to altered function of immunoregulatory T cell subpopulations, phenotypic and functional characteristics of CD4+ T cells were examined. The proportion of CD4+ T cells expressing the Leu‐8 and CD45R antigens was normal in patients with primary biliary cirrhosis.

Mechanisms of a clonidine‐induced decrease in portal pressure in normal and cirrhotic conscious rats

Dominique Roulot, Alain Braillon, Christophe Gaudin, Yves Ozier, Catherine Girod, Didier Lebrec – 1 October 1989 – The effects of clonidine on portal pressure and splanchnic blood flow were studied in conscious rats with sinusoidal portal hypertension due to cirrhosis induced by bile duct ligation. In cirrhotic and sham‐operated rats, clonidine (20 μg per kg body weight, intravenously) significantly reduced portal, pressure from 19.0 ± 0.6 to 14.5 ± 1.0 mmHg and from 9.8 ± 0.9 to 7.3 ± 0.5 mmHg, respectively. No significant change in systemic hemodynamics was observed.

The intralobular distribution of ethanol‐inducible P450IIE1 in rat and human liver

Mikihiro Tsutsumi, Jerome M. Lasker, Masanori Shimizu, Alan S. Rosman, Charles S. Lieber – 1 October 1989 – Perivenular hepatocytes are the first cells within the liver lobule to display signs of toxicity following long‐term alcohol use. In an attempt to explain this phenomenon, we have examined the hepatic intralobular distribution in rats and man of P450IIE1, a P‐450 isozyme that not only oxidizes ethanol but is also inducible by this agent.

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