Ellen Kahn, James Markowitz, Harvey Aiges, Fredric Daum – 1 July 1989 – Paucity of interlobular bile ducts is a common feature of cholestatic liver disease in premature infants. Whereas a bile duct to portal space ratio of 0.9 to 1.8 is cited by Alagille as the norm for children, there are no data regarding the normal bile duct to portal space ratio in preterm infants. In this study, by examining liver tissue obtained from autopsied fetuses and infants, we have determined that the bile duct to portal space ratio increases as a function of postconceptional age.

James G. Corasanti, Neil D. Smith, Ellen R. Gordon, James L. Boyer – 1 July 1989 – The role of hormones in the regulation of bile secretion is not known; however vasoactive agents, which act via the phosphoinositide signal transduction pathway, may mediate changes in bile flow by altering the hepatic microvasculature.

Erik Christensen – 1 July 1989

Takashi Kanematsu, Toshiya Furuta, Kenji Takenaka, Takashi Matsumata, Yasuhiro Yoshida, Takashi Nishizaki, Kanehiro Hasuo, Keizo Sugimachi – 1 July 1989 – Between 1982 and 1987, selective regional cancer chemotherapy using Lipiodol plus an anticancer drug (lipiodolization) was prescribed for 200 patients with hepatocellular carcinoma. One hundred forty‐nine patients were given lipiodolization alone, and the remaining 51 underwent hepatic resection following lipiodolization.

Hans‐Georg Leser, Axel Holstege, Wolfgang Gerok – 1 July 1989 – Adenosine‐degrading enzymes within the liver lobule can modulate both vascular and metabolic effects of circulating adenosine in the liver. Since it has not been fully established whether nonparenchymal cells participate in the elimination of sinusoidal purines, isolated Kupffer cells and endothelial cells were tested for their capacity to degrade extracellular purines. After perfusion and digestion of rat livers by collagenase, the resulting mixed cell population was separated by centrifugal elutriation.

P. Nico Lelie, Peter J. A. J. van Amelsfoort, C. S. Martine de Groot, Ed Bakker, Wim Schaasberg, Jos C. M. Niessen, Henk W. Reesink – 1 July 1989 – In a randomized, dose‐response study among 305 health care workers, we examined whether the immunogenicity of a heat‐inactivated hepatitis B vaccine could be enhanced when HBsAg was complexed by anti‐HBs contained in hepatitis B immunoglobulin either at equivalent proportions or at 10‐fold antigen excess.

Wouter H. Lamers, Aage Hilberts, Erwin Furt, Jerry Smith, Geertruida N. Jonges, Cornelis J. F. van Noorden, Jan Willem Gaasbeek Janzen, Robert Charles, Antoon F. M. Moorman – 1 July 1989 – The distribution pattern of a periportal enzyme (carbamoylphosphate synthetase) and a pericentral enzyme (glutamine synthetase) in human and rat liver has provided an objective parameter to delineate the zonal boundaries of the liver acinus.

E. J. L. Heathcote – 1 July 1989

Richard Moreau, Dominique Roulot, Alain Braillon, Christophe Gaudin, Antoine Hadengue, Yannick Bacq, Didier Lebrec – 1 July 1989 – High doses of nitroglycerin may decrease portal pressure in patients with cirrhosis with untoward effects such as arterial hypotension and a decrease in systemic O2 uptake.

Tomasz I. Michalak, Robert L. Snyder, Norma D. Churchill – 1 July 1989 – Interaction between woodchuck hepatitis virus surface antigen and proteins of hepatocyte plasma membranes were examined in the course of woodchuck hepatitis virus infection.