Biologic significance of the detection of HBsAg and HBcAg in liver and tumor from 204 HBsAg‐positive patients with primary hepatocellular carcinoma
Hey‐Chi Hsu, Tsung‐Teh Wu, Jin‐Chuan Sheu, Chieng‐Yen Wu, Tzyy‐Jen Chiou, Chu‐Shue Lee, Ding‐Shinn Chen – 1 May 1989 – Hepatitis B virus surface and core antigens (HBsAg, HBcAg) were examined in the resected primary hepatocellular carcinoma from 204 patients who had HBsAg in serum. Ninety patients had small (<5 cm) and 114 had large hepatocellular carcinoma (>5 cm).
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1 May 1989
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1 May 1989
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Sarah C. Kalser – 1 May 1989
Do transplanted human livers regenerate?
Katherine S. Koch, Hyam L. Leffert – 1 May 1989 – Two individuals undergoing orthotopic hepatic transplantation received livers from donors who were on average 10 kg smaller than themselves based on recipient ideal body weight. As a result, the donor livers in these 2 cases were 29%‐59% smaller than would be expected had the donor liver and recipient been matched ideally.
Hepatic mitochondrial oxidative metabolism and lipid peroxidation in experimental hexachlorobenzene‐induced porphyria with dietary carbonyl iron overload
Edward S. Feldman, Bruce R. Bacon – 1 May 1989 – Both human porphyria cutanea tarda and experimental hexachlorobenzene‐induced porphyria are associated with hepatic injury and are potentiated by excess hepatic iron. The mechanisms whereby cellular injury occurs and the synergistic role of iron overload are unknown. In the present experiments, we studied hepatic mitochondrial function and lipid peroxidation in rats with hexachlorobenzene‐induced porphyria in which iron loading was achieved by dietary carbonyl iron supplementation.
Amiodarone hepatotoxicity: Prevalence and clinicopathologic correlations among 104 patients
James H. Lewis, Richard C. Ranard, Anthony Caruso, Lawrence K. Jackson, Florabel Mullick, Kamal G. Ishak, Leonard B. Seeff, Hyman J. Zimmerman – 1 May 1989 – The prevalence of apparent amiodarone‐related hepatic injury in 104 patients followed prospectively is compared to that reported in the literature. Asymptomatic elevation of serum aminotransferase levels was detected in approximately one‐fourth of the patients, a figure similar to the average of reported cases. The frequency of extrahepatic organ toxicity was increased in patients with elevated levels.
Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in man
Jacqueline Loeper, Véronique Descatoire, Gilles Amouyal, Philippe Lettéron, Dominique Larrey, Dominique Pessayre – 1 May 1989 – Isaxonine and several other drugs transformed by cytochrome P‐450 into reactive metabolites apparently lead to immunoallergic hepatitis in man. Protein epitopes modified by the covalent binding of the metabolites have been proposed as possible targets for the immune response. The purpose of this work was to determine whether covalently bound metabolites are indeed present on hepatocyte plasma membrane proteins.