The Aminopyrine Breath Test and Serum Bile Acids Reflect Histologic Severity in Chronic Hepatitis

Paul S. Monroe, Alfred L. Baker, John F. Schneider, Patricia S. Krager, Peter D. Klein, Dale Schoeller – 1 May 1982 – To determine whether the aminopyrine breath test (ABT) and serum bile acid concentrations reflect histologic severity of chronic hepatitis, 56 patients were prospectively evaluated with liver biopsies and ABTs, and the results were compared to results of standard liver chemistry tests; 44 of these patients also had fasting and 2‐hr postprandial serum bile acid measurements.

A Prospective Morphologic Evaluation of Hepatic Toxicity of Chenodeoxycholic Acid in Patients with Cholelithiasis: The National Cooperative Gallstone Study

Rosemarie L. Fisher, Deborah W. Anderson, James L. Boyer, Kamal Ishak, Gerald Klatskin, John M. Lachin, M. James Phillips, The Steering Committee, The National Cooperative Gallstone Study Group – 1 March 1982 – A sample of 126 patients with cholelithiasis was treated with chenodeoxycholic acid (CDCA) (375 or 750 mg g.d.) for 2 years. Hepatotoxicity was assessed by sequential light (LM) and electron microscopic (EM) analysis of liver biopsies obtained before and after 9 and 24 months of therapy.

Triton WR‐1339, A Lysosomotropic Compound, Is Excreted into Bile and Alters the Biliary Excretion of Lysosomal Enzymes and Lipids

Nicholas F. Larusso, Louis J. Kost, Janet A. Carter, Steven S. Barham – 1 March 1982 – In these experiments, we tested two hypotheses: first, that Triton WR‐1339, a nonionic detergent which is sequestered in hepatocyte lysosomes, undergoes biliary excretion; and second, that Triton WR‐1339, which also alters serum lipid levels and modifies hepatic catabolism of lipoproteins, affects the biliary output of proteins and lipids.

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