Hyman J. Zimmerman – 1 March 1982

Howard C. Thomas, David Brown, Guitaine Routhier, George Janossy, Patrick C. Kung, Gideon Goldstein, Sheila Sherlock – 1 March 1982 – During acute type B hepatitis, the proportion of inducer to cytotoxic/suppressor T‐cells is decreased due to an increase in the concentration of suppressor cells. Similar changes are seen in chronically infected subjects with evidence of active viral replication (HBeAg positive) and chronic hepatitis of varying severity.

Stephan G. M. Meuwissen, Kurt P. Dingemans, Anneke Strijland, Joseph M. Tager, Bert C. M. Ooms – 1 March 1982 – Ultrastructural and biochemical analyses were made of liver biopsy material from a patient with longstanding Fabry's disease. Both hepatocytes as well as periportal macrophages showed lipid accumulations consisting of amorphous material as well as stacks of lamellar leaflets. Lipid inclusions in periportal macrophages were much larger than in hepatocytes. Furthermore, small round spheres were found exclusively in periportal macrophages.

Michael Manns, Karl‐Hermann Meyer, Zum Büschenfelde – 1 January 1982 – A radioimmunoassay (RIA) was established for the detection of antimitochondrial autoantibodies (AMAs) in patient sera. AMAs were detected by RIA in 12 of 14 patients with primary biliary cirrhosis and in 3 of 29 patients with chronic active hepatitis. AMAs were detected by indirect immunofluorescence in all sera positive by RIA.

Bernhard H. Lauterburg, Jerry R. Mitchell – 1 January 1982 – The effect of a toxic dose of acetaminophen on hepatic glutathione turnover was studied in fed and fasted rats. Following the administration of 1 gm per kg of acetaminophen, the fractional rate of glutathione turnover increased from 0.19 to 0.28 hr−1 in fed rats and from 0.43 to 0.50 hr−1 in rats fasted for 48 hr. The increase in the fractional rate of turnover was proportionally much less than the decrease in hepatic glutathione concentration resulting from the toxic dose of acetaminophen.

Don P. Jones – 1 January 1982

Vernon Campbell, Paul D. Greig, Jeff Cranford, Bernard Langer, Melvin Silverman, Laurence M. Blendis – 1 January 1982 – To define the relationship between portal hypertension and renal excretion of salt and water, two acute animal models of portal hypertension were investigated. In both models, it was necessary for systemic and renal hemodynamics to remain unchanged during the creation of portal hypertension so as to eliminate the effects of change in these parameters on renal excretion.

W. John Kalk, Michael C. Kew, Mervyn D. Danilewitz, Frederick Jacks, L. Andre Van Der Walt, Joseph Levin – 1 January 1982 – To determine the prevalence of elevated serum concentrations of thyroxine binding globulin (TBG) in patients with hepatocellular carcinoma (HCC) and the influence of the associated cirrhosis, TBG was measured in 39 patients with HCC, 22 with and 17 without cirrhosis, in 20 patients with cryptogenic macronodular cirrhosis but without HCC, and in 40 matched controls.

Stanley J. Wolfe – 1 January 1982

Bruno Voss, Jürgen Rauterberg, Gerhard Pott, Ute Brehmer, Salah Allam, Rolf Lehmann, Dirk B. V. Bassewitz – 1 January 1982 – Tissue specimens from human fibrotic liver obtained by needle biopsy were cultured. Two cell types emerged from the tissue explants. From their morphology and biosynthetic products they resembled smooth muscle cells and endothelial cells from blood vessel walls. In the “endothelial” cells, factor VIII‐associated protein was demonstrated by indirect immunofluorescence.