Recent Improvement in Survival Outcomes and Reappraisal of Prognostic Factors in Pediatric Living Donor Liver Transplantation

Seak Hee Oh, In Sook Jeong, Dae Yeon Kim, Jung‐Man Namgoong, Won Kyoung Jhang, Seong Jong Park, Dong‐Hwan Jung, Deok Bog Moon, Gi‐Won Song, Gil‐Chun Park, Tae‐Yong Ha, Chul‐Soo Ahn, Ki‐Hun Kim, Shin Hwang, Sung Gyu Lee, Kyung Mo Kim – 17 September 2021 – Living donor liver transplantation (LDLT) is a significant advancement for the treatment of children with end‐stage liver disease given the shortage of deceased donors. The ultimate goal of pediatric LDLT is to achieve complete donor safety and zero recipient mortality.

Current and Emerging Tools for Hepatocellular Carcinoma Surveillance

Nia Adeniji, Renumathy Dhanasekaran – 16 September 2021 – Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related mortality worldwide. Early detection of HCC enables patients to avail curative therapies that can improve patient survival. Current international guidelines advocate for the enrollment of patients at high risk for HCC, like those with cirrhosis, in surveillance programs that perform ultrasound every 6 months.

Genome‐Wide Association Study of NAFLD Using Electronic Health Records

Cameron J. Fairfield, Thomas M. Drake, Riinu Pius, Andrew D. Bretherick, Archie Campbell, David W. Clark, Jonathan A. Fallowfield, Caroline Hayward, Neil C. Henderson, Peter K. Joshi, Nicholas L. Mills, David J. Porteous, Prakash Ramachandran, Robert K. Semple, Catherine A. Shaw, Cathie L.M. Sudlow, Paul R.H.J. Timmers, James F. Wilson, Stephen J. Wigmore, Ewen M. Harrison, Athina Spiliopoulou – 16 September 2021 – Genome‐wide association studies (GWAS) have identified several risk loci for nonalcoholic fatty liver disease (NAFLD).

A Mesenchymal‐Epithelial Transition Factor‐Agonistic Antibody Accelerates Cirrhotic Liver Regeneration and Improves Mouse Survival Following Partial Hepatectomy

Kuai Ma, Weitao Que, Xin Hu, Wen‐Zhi Guo, Er‐li Gu, Liang Zhong, Virginia Morello, Manuela Cazzanti, Paolo Michieli, Terumi Takahara, Xiao‐Kang Li – 15 September 2021 – Small‐for‐size syndrome (SFSS) is a common complication following partial liver transplantation and extended hepatectomy. SFSS is characterized by postoperative liver dysfunction caused by insufficient regenerative capacity and portal hyperperfusion and is more frequent in patients with preexisting liver disease.

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