Evaluating Outcomes Related to Donor and Recipient Metabolic Environment: Macrosteatotic Allografts and Nonalcoholic Steatohepatitis

Peter J. Altshuler, Hien Dang, Adam M. Frank, Ashesh P. Shah, Jaime Glorioso, Tingting Zhan, Arturo Rios Diaz, Osama Shaheen, Carlo B. Ramirez, Warren R. Maley, Adam S. Bodzin – 25 September 2021 – The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) affects both recipient and donor populations in liver transplantation. Presently, it is unclear whether transplantation of macrosteatotic allografts is affected by the metabolic milieu of liver transplant recipients.

Seroconversion After Coronavirus Disease 2019 Vaccination in Patients Awaiting Liver Transplantation: Fact or Fancy?

Alberto Calleri, Margherita Saracco, Fabrizia Pittaluga, Rossana Cavallo, Renato Romagnoli, Silvia Martini – 25 September 2021 – Chronic liver disease increased the risk of severe coronavirus disease 2019 (COVID‐19). Trials to assess efficacy/safety of COVID‐19 vaccines in liver disease are underway. We evaluated the humoral immune response and safety of anti–COVID‐19 vaccination among patients waiting liver transplantation (LT). We enrolled all pre‐LT adults who completed anti‐COVID‐19 vaccination between January 2021‐August 2021 as study group.

Offer Acceptance Patterns for Liver Donors Aged 70 and Older

Christine E. Haugen, Mary G. Bowring, Kyle R. Jackson, Jacqueline Garonzik‐Wang, Allan B. Massie, Teresa Po‐Yu Chiang, Benjamin Philosophe, Dorry L. Segev, Karim J. Halazun – 23 September 2021 – Despite a documented survival benefit, older liver donor (OLD, age ≥70) graft offers are frequently declined, with utilization worsening over the last decade. To understand how offer acceptance varies by center, we studied 1113 eventually transplanted OLD grafts from 2009 to 2017 using Scientific Registry of Transplant Recipients (SRTR) data and random‐intercept multilevel logistic regression.

Impact of Race‐Adjusted Glomerular Filtration Rate Estimation on Eligibility for Simultaneous Liver‐Kidney Transplantation

Sarjukumar Panchal, Marina Serper, Therese Bittermann, Sumeet K. Asrani, David S. Goldberg, Nadim Mahmud – 23 September 2021 – Estimated glomerular filtration rate (eGFR) is adjusted for Black race in commonly used formulas. This has potential implications for access to simultaneous liver‐kidney transplantation (SLKT) as qualifying criteria rely on eGFR.

Health‐Related Quality of Life and Its Contributors According to a Preference‐Based Generic Instrument in Cirrhosis

Yangyang Hui, Nan Li, Zihan Yu, Chaoqun Li, Xiaoyu Wang, Yifan Li, Mingyu Sun, Wanting Yang, Gaoyue Guo, Xiaofei Fan, Lin Lin, Binxin Cui, Xin Chen, Bangmao Wang, Jie Zhang, Chao Sun – 23 September 2021 – It is essential to determine contributors around impairment in health‐related quality of life (HRQoL) in patients with cirrhosis aiming at improving health care and therapeutic strategy.

Hepatology Highlights

Chaitanya Allamneni, Ravi S. Vora, Adebowale O. Bamidele, Robert E. Schwartz, Davide Povero, David M. Salerno, Robert S. Brown, Rosa Lu Yu, Mati Ullah Dad Ullah, Daryl T.Y. Lau, Wei Zhang, Amani Lee, Enis Kostallari, Nidhi Jalan‐Sakrikar, Shalil Khanal, Enis Kostallari – 23 September 2021

Nonmalignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin‐rich thrombus

Ellen G. Driever, Fien A. Meijenfeldt, Jelle Adelmeijer, Robbert J. Haas, Marius C. den Heuvel, Chandrasekaran Nagasami, John W. Weisel, Constantino Fondevila, Robert J. Porte, Anabel Blasi, Nigel Heaton, Stephen Gregory, Pauline Kane, William Bernal, Yoh Zen, Ton Lisman – 23 September 2021

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