Macrophage nuclear factor erythroid 2‐related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3–mediated RhoA/ROCK pathway in the ischemic liver

A Meta‐Analysis and Systematic Review on the Global Prevalence, Risk Factors, and Outcomes of Coronary Artery Disease in Liver Transplantation Recipients

Jieling Xiao, Jie Ning Yong, Cheng Han Ng, Nicholas Syn, Wen Hui Lim, Darren Jun Hao Tan, En Ying Tan, Daniel Huang, Raymond C. Wong, Nicholas W. S. Chew, Eunice Xiang Xuan Tan, Mazen Noureddin, Mohammad Shadab Siddiqui, Mark D. Muthiah – 7 October 2021 – The shift in the changing etiology of cirrhosis requiring liver transplantation (LT) has resulted in an increasing prevalence of coronary artery disease (CAD) that can potentially impact post‐LT outcomes.

Introduction of the Concept of Diagnostic Sensitivity and Specificity of Normothermic Perfusion Protocols to Assess High‐Risk Donor Livers

Hynek Mergental, Richard W. Laing, James Hodson, Yuri L. Boteon, Joseph A. Attard, Laine L. Walace, Desley A. H. Neil, Darren Barton, Andrea Schlegel, Paolo Muiesan, Manuel Abradelo, John R. Isaac, Keith Roberts, M. Thamara P. R. Perera, Simon C. Afford, Darius F. Mirza – 6 October 2021 – Normothermic machine perfusion (NMP) allows objective assessment of donor liver transplantability. Several viability evaluation protocols have been established, consisting of parameters such as perfusate lactate clearance, pH, transaminase levels, and the production and composition of bile.

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Alberto Calleri, Margherita Saracco, Fabrizia Pittaluga, Rossana Cavallo, Renato Romagnoli, Silvia Martini – 6 October 2021

Redefining Success After Liver Transplantation: From Mortality Toward Function and Fulfillment

Marina Serper, Sumeet Asrani, Lisa VanWagner, Peter P. Reese, Minjee Kim, Michael S. Wolf – 4 October 2021 – Liver transplantation (LT), the only cure for end‐stage liver disease, is a lifesaving, costly, and limited resource. LT recipients (LTRs) are aging with an increasing burden of medical comorbidities. Patient and graft survival rates exceed 70% at 5 years; however, patient‐centered health outcomes beyond survival have received relatively little attention.

Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours

Angus Hann, Hanns Lembach, Anisa Nutu, Hynek Mergental, John L. Isaac, John R. Isaac, Ye H. Oo, Matthew J. Armstrong, Neil Rajoriya, Simon Afford, David Bartlett, Darius F. Mirza, Hermien Hartog, M. Thamara P.R. Perera – 3 October 2021

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