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Introduction of the Concept of Diagnostic Sensitivity and Specificity of Normothermic Perfusion Protocols to Assess High‐Risk Donor Livers

Read more about Introduction of the Concept of Diagnostic Sensitivity and Specificity of Normothermic Perfusion Protocols to Assess High‐Risk Donor Livers

Hynek Mergental, Richard W. Laing, James Hodson, Yuri L. Boteon, Joseph A. Attard, Laine L. Walace, Desley A. H. Neil, Darren Barton, Andrea Schlegel, Paolo Muiesan, Manuel Abradelo, John R. Isaac, Keith Roberts, M. Thamara P. R. Perera, Simon C. Afford, Darius F. Mirza – 6 October 2021 – Normothermic machine perfusion (NMP) allows objective assessment of donor liver transplantability. Several viability evaluation protocols have been established, consisting of parameters such as perfusate lactate clearance, pH, transaminase levels, and the production and composition of bile.

GALAD demonstrates high sensitivity for HCC surveillance in a cohort of patients with cirrhosis

Read more about GALAD demonstrates high sensitivity for HCC surveillance in a cohort of patients with cirrhosis

Amit G. Singal, Nabihah Tayob, Anand Mehta, Jorge A. Marrero, Hashem El‐Serag, Qingchun Jin, Cristian Saenz de Viteri, Austin Fobar, Neehar D. Parikh – 6 October 2021

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Alberto Calleri, Margherita Saracco, Fabrizia Pittaluga, Rossana Cavallo, Renato Romagnoli, Silvia Martini – 6 October 2021

Redefining Success After Liver Transplantation: From Mortality Toward Function and Fulfillment

Read more about Redefining Success After Liver Transplantation: From Mortality Toward Function and Fulfillment

Marina Serper, Sumeet Asrani, Lisa VanWagner, Peter P. Reese, Minjee Kim, Michael S. Wolf – 4 October 2021 – Liver transplantation (LT), the only cure for end‐stage liver disease, is a lifesaving, costly, and limited resource. LT recipients (LTRs) are aging with an increasing burden of medical comorbidities. Patient and graft survival rates exceed 70% at 5 years; however, patient‐centered health outcomes beyond survival have received relatively little attention.

Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours

Read more about Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours

Angus Hann, Hanns Lembach, Anisa Nutu, Hynek Mergental, John L. Isaac, John R. Isaac, Ye H. Oo, Matthew J. Armstrong, Neil Rajoriya, Simon Afford, David Bartlett, Darius F. Mirza, Hermien Hartog, M. Thamara P.R. Perera – 3 October 2021

MicroRNA‐206 enhances antitumor immunity by disrupting the communication between malignant hepatocytes and regulatory T cells in c‐Myc mice

Read more about MicroRNA‐206 enhances antitumor immunity by disrupting the communication between malignant hepatocytes and regulatory T cells in c‐Myc mice

Ningning Liu, Clifford J. Steer, Guisheng Song – 3 October 2021

BMS‐986263 in patients with advanced hepatic fibrosis: 36‐week results from a randomized, placebo‐controlled phase 2 trial

Read more about BMS‐986263 in patients with advanced hepatic fibrosis: 36‐week results from a randomized, placebo‐controlled phase 2 trial

Eric J. Lawitz, Diane E. Shevell, Giridhar S. Tirucherai, Shuyan Du, Warner Chen, Uma Kavita, Angie Coste, Fred Poordad, Morten Karsdal, Mette Nielsen, Zachary Goodman, Edgar D. Charles – 3 October 2021

E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants

Read more about E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants

Yao Yang, Jinjung Choi, Ying Chen, Pietro Invernizzi, Guoxiang Yang, Weici Zhang, Ti‐hong Shao, Frank Jordan, Natalia S. Nemeria, Ross L. Coppel, William M. Ridgway, Mark Kurth, Aftab A. Ansari, Patrick S.C. Leung, M. Eric Gershwin – 3 October 2021

Infusion of Allogeneic Mesenchymal Stromal Cells After Liver Transplantation: A 5‐Year Follow‐Up

Read more about Infusion of Allogeneic Mesenchymal Stromal Cells After Liver Transplantation: A 5‐Year Follow‐Up

Morgan Vandermeulen, Maleyko Mohamed‐Wais, Pauline Erpicum, Marie‐Hélène Delbouille, Chantal Lechanteur, Alexandra Briquet, Gianni Maggipinto, François Jouret, Yves Beguin, Olivier Detry – 2 October 2021 – Various properties of mesenchymal stromal cells (MSCs) might be particularly of interest after liver transplantation (LT). In this article, we report the long‐term results of a prospective, controlled, and first‐in‐human phase 1 study evaluating the safety of a single MSC infusion after LT.

Associations Between Alcohol Use and Liver‐Related Outcomes in a Large National Cohort of Patients With Cirrhosis

Read more about Associations Between Alcohol Use and Liver‐Related Outcomes in a Large National Cohort of Patients With Cirrhosis

Meredith M. Pearson, Nicole J. Kim, Kristin Berry, Andrew M. Moon, Feng Su, Philip Vutien, Pamela K. Green, Emily C. Williams, George N. Ioannou – 2 October 2021 – Alcohol use can cause hepatic necroinflammation and worsening portal hypertension in patients with cirrhosis. We aimed to evaluate the associations between degree of alcohol use and clinical liver‐related outcomes according to etiology of cirrhosis. In this retrospective cohort analysis, 44,349 U.S.

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