Covid‐19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis

Matthew J. McConnell, Reiichiro Kondo, Nao Kawaguchi, Yasuko Iwakiri – 17 October 2021 – Liver injury, characterized predominantly by elevated aspartate aminotransferase and alanine aminotransferase, is a common feature of coronavirus disease 2019 (COVID‐19) symptoms caused by severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). Additionally, SARS‐CoV‐2 infection is associated with acute‐on‐chronic liver failure in patients with cirrhosis and has a notably elevated mortality in patients with alcohol‐related liver disease compared to other etiologies.

Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis

Arun J. Sanyal, Quentin M. Anstee, Michael Trauner, Eric J. Lawitz, Manal F. Abdelmalek, Dora Ding, Ling Han, Catherine Jia, Ryan S. Huss, Chuhan Chung, Vincent Wai‐Sun Wong, Takeshi Okanoue, Manuel Romero‐Gomez, Andrew J. Muir, Nezam H. Afdhal, Jaime Bosch, Zachary Goodman, Stephen A. Harrison, Zobair M. Younossi, Robert P. Myers – 17 October 2021

N‐acetylgalactosaminyltransferase‐4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal‐regulating kinase 1 N‐terminal dimerization

Jiangqiao Zhou, Lina Guo, Tengfei Ma, Tao Qiu, Sichen Wang, Song Tian, Li Zhang, Fengjiao Hu, Wei Li, Zhen Liu, Yufeng Hu, Tianyu Wang, Chenyang Kong, Juan Yang, Junjie Zhou, Hongliang Li – 17 October 2021

Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol‐associated hepatitis

Kunpeng Hu, Maria C. Perez‐Matos, Josepmaria Argemi, Eduardo Vilar‐Gomez, Irina Shalaurova, Esther Bullitt, Lee Landeen, Go Sugahara, Huiyan Deng, Karan Mathur, Stephanie Tran, Huimei Cai, Hanchang He, Yusuf Yalcin, Joana Vieira Barbosa, Meritxell Ventura‐Cots, Katherine Marx, Aniket P. Gad, Sebastian Niezen, Sofia Izunza Barba, Lay‐Hong Ang, Yury V. Popov, Zachary Fricker, Michelle Lai, Michael Curry, Nezam Afdhal, Gyongyi Szabo, Kenneth J. Mukamal, Arun J. Sanyal, James D. Otvos, Raza Malik, Takeshi Saito, Margery A. Connelly, Naga P. Chalasani, Ramon Bataller, Z.

Circulating Tumor Cell–Based Messenger RNA Scoring System for Prognostication of Hepatocellular Carcinoma: Translating Tissue‐Based Messenger RNA Profiling Into a Noninvasive Setting

Yi‐Te Lee, Na Sun, Minhyung Kim, Jasmine J. Wang, Benjamin V. Tran, Ryan Y. Zhang, Dongping Qi, Ceng Zhang, Pin‐Jung Chen, Saeed Sadeghi, Richard S. Finn, Sammy Saab, Steven‐Huy B. Han, Ronald W. Busuttil, Renjun Pei, Yazhen Zhu, Hsian‐Rong Tseng, Sungyong You, Ju Dong Yang, Vatche G. Agopian – 17 October 2021 – Numerous studies in hepatocellular carcinoma (HCC) have proposed tissue‐based gene signatures for individualized prognostic assessments.

International Population Study in Spain, Cuba, and the United States of Attitudes Toward Organ Donation Among the Cuban Population

Antonio Ríos, Alvaro Sánchez‐Martínez, Marco Antonio Ayala‐García, Pedro R. Gutiérrez, Gerardo Palacios, Marina Iniesta‐Sepúlveda, Pablo Ramírez, Ana Isabel López‐Navas – 17 October 2021 – Cuban immigrants constitute an important group in both the United States and Spain, with different behaviors toward organ donation having been described among the different Latin American nationalities. We analyzed the attitude toward organ donation among the Cuban populations in Cuba, Spain, and Florida.

Increased Expressions of Programmed Death Ligand 1 and Galectin 9 in Transplant Recipients Who Achieved Tolerance After Immunosuppression Withdrawal

Nguyen Hai Nam, Kojiro Taura, Yukinori Koyama, Takahiro Nishio, Gen Yamamoto, Yusuke Uemoto, Yusuke Kimura, Li Xuefeng, Daichi Nakamura, Kenji Yoshino, Eri Ogawa, Tatsuya Okamoto, Atsushi Yoshizawa, Satoru Seo, Keiko Iwaisako, Tomoaki Yoh, Koichiro Hata, Toshihiko Masui, Hideaki Okajima, Hironori Haga, Shinji Uemoto, Etsuro Hatano – 15 October 2021 – Programmed death 1 (PD1)/its ligand PD‐L1 concomitant with T cell immunoglobulin and mucin domain‐containing protein 3 (TIM‐3)/its ligand galectin 9 (Gal‐9) and the forkhead box P3 (FOXP3) might be involved in tolerance after liver transpl

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