Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice

Samuel C. Buchl, Zachary Hanquier, Andrew J. Haak, Yvonne M. Thomason, Robert C. Huebert, Vijay H. Shah, Jessica L. Maiers – 21 October 2021 – Hepatic fibrosis is driven by deposition of matrix proteins following liver injury. Hepatic stellate cells (HSCs) drive fibrogenesis, producing matrix proteins, including procollagen I, which matures into collagen I following secretion. Disrupting intracellular procollagen processing and trafficking causes endoplasmic reticulum stress and stress‐induced HSC apoptosis and thus is an attractive antifibrotic strategy.

Hepatocellular Carcinoma Risk Assessment for Patients With Advanced Fibrosis After Eradication of Hepatitis C Virus

Nobuharu Tamaki, Masayuki Kurosaki, Yutaka Yasui, Nami Mori, Keiji Tsuji, Chitomi Hasebe, Kouji Joko, Takehiro Akahane, Koichiro Furuta, Haruhiko Kobashi, Hiroyuki Kimura, Hitoshi Yagisawa, Hiroyuki Marusawa, Masahiko Kondo, Yuji Kojima, Hideo Yoshida, Yasushi Uchida, Toshifumi Tada, Shinichiro Nakamura, Satoshi Yasuda, Hidenori Toyoda, Rohit Loomba, Namiki Izumi – 21 October 2021 – The identification of patients with advanced fibrosis who do not need any further hepatocellular carcinoma (HCC) surveillance after the eradication of hepatitis C is pivotal.

Low Lipoprotein(a) Levels Predict Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Marica Meroni, Miriam Longo, Rosa Lombardi, Erika Paolini, Chiara Macchi, Alberto Corsini, Cesare R. Sirtori, Anna Ludovica Fracanzani, Massimiliano Ruscica, Paola Dongiovanni – 21 October 2021 – Dyslipidemia and cardiovascular complications are comorbidities of nonalcoholic fatty liver disease (NAFLD), which ranges from simple steatosis to nonalcoholic steatohepatitis, fibrosis, and cirrhosis up to hepatocellular carcinoma.

Hepatology Highlights

Alyson Kaplan, Robert S. Brown, Adam Buckholz, Thuy‐Van P. Hang, Preeti A. Reshamwala, Jessica L. Maiers, Robert E. Schwartz, Wei Zhang, Shalil Khanal, Enis Kostallari, Adebowale O. Bamidele, Amani Lee, Enis Kostallari, Mati Ullah Dad Ullah, Daryl T.Y. Lau, Davide Povero, Nabeel Wahid, Russell Rosenblatt – 20 October 2021

LiverLearning®: 2021 Webinar: AASLD’s Thought Leaders Series: How I Manage My Practice

This 60-minute discussion, held Wednesday, October 20 th and hosted by AASLD President, Dr. Ray Chung, FAASLD of Massachusetts General, included interviews with NAFLD/NASH experts, Dr. Mary Rinella, FAASLD of Northwestern University and Dr. Anna Mae Diehl, FAASLD of Duke University. Our experts delved into how they manage their practices in fatty liver, how their institutions and multidisciplinary teams work together, diagnostic and treatment solutions to NAFLD, and more. This webinar is the first of a new program, AASLD's Thought Leaders Series: How I Manage My Practice .

Malnutrition in Biliary Atresia: Assessment, Management, and Outcomes

Julia M. Boster, Amy G. Feldman, Cara L. Mack, Ronald J. Sokol, Shikha S. Sundaram – 19 October 2021 – Children with biliary atresia (BA), particularly infants, are at high risk for malnutrition attributed to a multitude of factors, including poor oral intake and intolerance of enteral feeding, fat malabsorption, abnormal nutrient metabolism, and increased caloric demand. Malnutrition and sarcopenia negatively impact outcomes in BA, leading to higher pretransplant and posttransplant morbidity and mortality.

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