Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia

Julie Osborn, Reena Mourya, Unmesha Thanekar, Weizhe Su, Lin Fei, Pranavkumar Shivakumar, Jorge A. Bezerra – 26 December 2021 – Children with biliary atresia (BA) often develop portal hypertension (PHT) and its complications, which are associated with high morbidity and mortality. The goal of this study was to identify serum biomarkers of PHT by using large‐scale proteomics.

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Hamish Innes, Hans Dieter Nischalke, Indra Neil Guha, Karl Heinz Weiss, Will Irving, Daniel Gotthardt, Eleanor Barnes, Janett Fischer, M. Azim Ansari, Jonas Rosendahl, Shang‐Kuan Lin, Astrid Marot, Vincent Pedergnana, Markus Casper, Jennifer Benselin, Frank Lammert, John McLauchlan, Philip L. Lutz, Victoria Hamill, Sebastian Mueller, Joanne R. Morling, Georg Semmler, Florian Eyer, Johann von Felden, Alexander Link, Arndt Vogel, Jens U.

Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation

Brittany Rocque, Aaron Zaldana, Carly Weaver, Julia Huang, Arianna Barbetta, Victoria Shakhin, Cameron Goldbeck, George Yanni, Shannon Zielsdorf, Yong Kwon, Kambiz Etesami, Yuri Genyk, Shengmei Zhou, Rohit Kohli, Juliet Emamaullee – 25 December 2021 – Although pediatric liver transplantation (LT) results in excellent long‐term outcomes, a high incidence of early acute cellular rejection and late graft fibrosis persists. Routine measurement of allograft enzymes may not reliably detect rejection episodes, identify candidates for immunosuppression minimization, or indicate allograft fibrosis.

Immunological Aspects of AXL/GAS‐6 in the Context of Human Liver Regeneration

Gregor Ortmayr, Laura Brunnthaler, David Pereyra, Heidemarie Huber, Jonas Santol, Benedikt Rumpf, Sina Najarnia, Rory Smoot, Daphni Ammon, Thomas Sorz, Fabian Fritsch, Michael Schodl, Astrid Voill‐Glaninger, Barbara Weitmayr, Manuela Födinger, Martin Klimpfinger, Thomas Gruenberger, Alice Assinger, Wolfgang Mikulits, Patrick Starlinger – 23 December 2021 – AXL and its corresponding ligand growth arrest–specific 6 (GAS‐6) are critically involved in hepatic immunomodulation and regenerative processes.

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