Leukocyte‐Derived High‐Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes

Annika Volmari, Katharina Foelsch, Elisabeth Zierz, Karsten Yan, Minyue Qi, Karlotta Bartels, Stephanie Kondratowicz, Marius Boettcher, Daniel Reimers, Masahiro Nishibori, Keyue Liu, Robert F. Schwabe, Ansgar W. Lohse, Samuel Huber, Hans‐Willi Mittruecker, Peter Huebener – 27 July 2021 – High‐mobility group box 1 (HMGB1) is a nucleoprotein with proinflammatory functions following cellular release during tissue damage.

Usefulness of Cell‐Free Human Telomerase Reverse Transcriptase Mutant DNA Quantification in Blood for Predicting Hepatocellular Carcinoma Treatment Efficacy

Masaru Muraoka, Shinya Maekawa, Ryo Katoh, Yasuyuki Komiyama, Natsuko Nakakuki, Hitomi Takada, Shuya Matsuda, Yuichiro Suzuki, Mitsuaki Sato, Akihisa Tatsumi, Mika Miura, Fumitake Amemiya, Hiroko Shindo, Shinichi Takano, Mitsuharu Fukasawa, Kozue Yamauchi, Tatsuya Yamaguchi, Yasuhiro Nakayama, Taisuke Inoue, Nobuyuki Enomoto – 27 July 2021 – Although the usefulness of liquid biopsy as a biomarker in the treatment of hepatocellular carcinoma (HCC) has been suggested, its usefulness in transcatheter arterial chemoembolization (TACE) or tyrosine kinase inhibitor (TKI) therapies has not been re

Mandatory Hepatology Education for Internal Medicine Residents: Long‐Term Effects and Implications for Workforce Needs

Adam E. Mikolajczyk, Netanel Zilberstein, John F. McConville, Alex Pan, Andrew I. Aronsohn, Helen S. Te, Gautham Reddy, Sonali Paul, Anjana Pillai, Michael Charlton, Jeanne M. Farnan – 27 July 2021 – We previously created a mandatory, inpatient, hepatology resident curriculum that immediately improved comfort, knowledge, and career interest in chronic liver disease (CLD). The durability of these effects needs to be known to use this intervention to address the hepatologist shortage.

Risk Prediction of Nosocomial and Posthospital Discharge Infections in Alcohol‐Associated Hepatitis

Daniel D. Penrice, Serena Shah, Camille A. Kezer, Thoetchai Bee Peeraphatdit, Arun J. Sanyal, Brian Davis, Kristin C. Mara, Vijay H. Shah, Patrick S. Kamath, Douglas A. Simonetto – 27 July 2021 – Alcohol‐associated hepatitis (AAH) is a severe form of liver injury with mortality as high as 30%‐40% at 90 days. As a result of altered immune function in AAH, bacterial infections are common and are associated with poor outcomes. However, determining the risk and subsequent development of infection in patients with AAH remain challenging.

Addressing Social Adversity to Improve Outcomes for Children After Liver Transplant

Sharad I. Wadhwani, Laura Gottlieb, John C. Bucuvalas, Courtney Lyles, Jennifer C. Lai – 27 July 2021 – The social determinants of health, defined as the conditions in which we live, learn, work, and play, undoubtedly impact health outcomes. Social adversity in childhood perpetuates over the life course and has consequences extending into adulthood. This link between social adversity and adverse outcomes extends to children undergoing liver transplant, with children from socioeconomically deprived neighborhoods experiencing a greater burden of morbidity and mortality after transplant.

LiverLearning®: 2021 Webinar: Genetics of NAFLD

In this webinar, you will learn how to describe nonalcoholic fatty liver disease (NAFLD) as it relates to genes in animal and human models, their role, function and related pathways. Also, the focus on NAFLD-related genes in human studies and their relationship to disease severity. Lastly, can you use the genes in a precision medicine approach?Silvia Sookoian Silvia Sookoian, MD, PhD, FAASLD is head of Clinical and Molecular Hepatology Department, Institute of Medical Research IDIM-National Scientific and Technical Research Council (CONICET), School of Medicine, University of Buenos Aires.

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