Usefulness of Cell‐Free Human Telomerase Reverse Transcriptase Mutant DNA Quantification in Blood for Predicting Hepatocellular Carcinoma Treatment Efficacy

Masaru Muraoka, Shinya Maekawa, Ryo Katoh, Yasuyuki Komiyama, Natsuko Nakakuki, Hitomi Takada, Shuya Matsuda, Yuichiro Suzuki, Mitsuaki Sato, Akihisa Tatsumi, Mika Miura, Fumitake Amemiya, Hiroko Shindo, Shinichi Takano, Mitsuharu Fukasawa, Kozue Yamauchi, Tatsuya Yamaguchi, Yasuhiro Nakayama, Taisuke Inoue, Nobuyuki Enomoto – 27 July 2021 – Although the usefulness of liquid biopsy as a biomarker in the treatment of hepatocellular carcinoma (HCC) has been suggested, its usefulness in transcatheter arterial chemoembolization (TACE) or tyrosine kinase inhibitor (TKI) therapies has not been re

Mandatory Hepatology Education for Internal Medicine Residents: Long‐Term Effects and Implications for Workforce Needs

Adam E. Mikolajczyk, Netanel Zilberstein, John F. McConville, Alex Pan, Andrew I. Aronsohn, Helen S. Te, Gautham Reddy, Sonali Paul, Anjana Pillai, Michael Charlton, Jeanne M. Farnan – 27 July 2021 – We previously created a mandatory, inpatient, hepatology resident curriculum that immediately improved comfort, knowledge, and career interest in chronic liver disease (CLD). The durability of these effects needs to be known to use this intervention to address the hepatologist shortage.

Risk Prediction of Nosocomial and Posthospital Discharge Infections in Alcohol‐Associated Hepatitis

Daniel D. Penrice, Serena Shah, Camille A. Kezer, Thoetchai Bee Peeraphatdit, Arun J. Sanyal, Brian Davis, Kristin C. Mara, Vijay H. Shah, Patrick S. Kamath, Douglas A. Simonetto – 27 July 2021 – Alcohol‐associated hepatitis (AAH) is a severe form of liver injury with mortality as high as 30%‐40% at 90 days. As a result of altered immune function in AAH, bacterial infections are common and are associated with poor outcomes. However, determining the risk and subsequent development of infection in patients with AAH remain challenging.

Addressing Social Adversity to Improve Outcomes for Children After Liver Transplant

Sharad I. Wadhwani, Laura Gottlieb, John C. Bucuvalas, Courtney Lyles, Jennifer C. Lai – 27 July 2021 – The social determinants of health, defined as the conditions in which we live, learn, work, and play, undoubtedly impact health outcomes. Social adversity in childhood perpetuates over the life course and has consequences extending into adulthood. This link between social adversity and adverse outcomes extends to children undergoing liver transplant, with children from socioeconomically deprived neighborhoods experiencing a greater burden of morbidity and mortality after transplant.

LiverLearning®: 2021 Webinar: Genetics of NAFLD

In this webinar, you will learn how to describe nonalcoholic fatty liver disease (NAFLD) as it relates to genes in animal and human models, their role, function and related pathways. Also, the focus on NAFLD-related genes in human studies and their relationship to disease severity. Lastly, can you use the genes in a precision medicine approach?Silvia Sookoian Silvia Sookoian, MD, PhD, FAASLD is head of Clinical and Molecular Hepatology Department, Institute of Medical Research IDIM-National Scientific and Technical Research Council (CONICET), School of Medicine, University of Buenos Aires.

Molecular Mismatch Predicts T Cell–Mediated Rejection and De Novo Donor‐Specific Antibody Formation After Living Donor Liver Transplantation

Kosuke Ono, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Naoki Tanimine, Hiroaki Yamane, Hideki Ohdan – 25 July 2021 – Human leukocyte antigen (HLA) molecular mismatch (MM) analysis improves the prediction of clinical outcomes in kidney transplantation compared with prediction via traditional antigen MM. However, it remains unclear whether the level of MM can be used for risk stratification among liver transplantation (LT) recipients.

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