Modeling PNPLA3‐Associated NAFLD Using Human‐Induced Pluripotent Stem Cells
Samantha G. Tilson, Carola M. Morell, An‐Sofie Lenaerts, Seung Bum Park, Zongyi Hu, Benjamin Jenkins, Albert Koulman, T. Jake Liang, Ludovic Vallier – 19 July 2021
IL‐1β‐Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up‐regulating Programmed Death Ligand 1 and Colony‐Stimulating Factor 1
Qin He, Mei Liu, Wenjie Huang, Xiaoping Chen, Bixiang Zhang, Tongyue Zhang, Yijun Wang, Danfei Liu, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia – 19 July 2021
COVID‐19 and the Uncovering of Health Care Disparities in the United States, United Kingdom and Canada: Call to Action
Aftab Ala, Julius Wilder, Naudia L. Jonassaint, Carla S. Coffin, Carla Brady, Andrew Reynolds, Michael L. Schilsky – 19 July 2021 – The coronavirus disease 2019 (COVID‐19) pandemic created a crisis that disproportionately affected populations already disadvantaged with respect to access to health care systems and adequate medical care and treatments. Understanding how and where health care disparities are most widespread is an important starting point for exploring opportunities to mitigate such disparities, especially within our patient population with liver disease.
The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin‐Mediated Degradation of 3‐Hydroxy‐3‐Methylglutaryl CoA Reductase Degradation Protein 1
Qin Yang, Xi Chen, Yanfang Zhang, Sha Hu, Fengjiao Hu, Yongping Huang, Tengfei Ma, Heng Hu, Han Tian, Song Tian, Yan‐Xiao Ji, Zhi‐Gang She, Peng Zhang, Xiao‐Jing Zhang, Yufeng Hu, Hailong Yang, Yufeng Yuan, Hongliang Li – 16 July 2021
To Transplant or Not to Transplant: Understanding and Assessing the Liver‐Kidney Allocation Policy
Parita V. Patel, Steven L. Flamm – 16 July 2021
Remembrance of a Passing Pandemic
Marcus R. Pereira, Jean C. Emond – 16 July 2021
Metabolomics to Predict Acute Kidney Injury in Cirrhosis
Salvatore Piano, Andres Cardenas – 15 July 2021
Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics
Magda Shaheen, Deyu Pan, Katrina M. Schrode, Dulcie Kermah, Vishwajeet Puri, Ali Zarrinpar, David Elisha, Sonia M. Najjar, Theodore C. Friedman – 15 July 2021 – Hepatic steatosis (HS) is a growing problem in adults worldwide, with racial/ethnic disparity in the prevalence of the disease. The purpose of this study was to characterize the racial/ethnic prevalence of the stages (normal/mild [S0/S1], moderate [S2], and severe [S3]) of HS in Mexican Americans and other Hispanics compared to other racial/ethnic groups.
Liver Abscess: Complications and Treatment
Sanchit Sharma, Vineet Ahuja – 15 July 2021
Tissue‐Specific Regulation of Ferroportin in Wild‐Type and Hjv‐/‐ Mice Following Dietary Iron Manipulations
Angeliki Katsarou, Konstantinos Gkouvatsos, Carine Fillebeen, Kostas Pantopoulos – 15 July 2021 – Hepcidin is a liver‐derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation. Genetic hepcidin inactivation leads to hereditary hemochromatosis, a disease of iron overload. We used wild‐type and Hjv‐/‐ mice, a model of hemochromatosis, to examine the expression of ferroportin and other proteins of iron metabolism in hepcidin target tissues.