Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell–Mediated Antitumor Immunity Through PD‐L1

Noreen Nog‐Qin Chui, Jacinth Wing‐Sum Cheu, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi‐Ching Goh, Derek Lee, Misty Shuo Zhang, Irene Oi‐Lin Ng, Carmen Chak‐Lui Wong – 20 July 2021 – Liver cancers consist primarily of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Immune checkpoint inhibitors have emerged as promising therapeutic agents against liver cancers. Programmed cell death protein 1 (PD‐1) is an immunoinhibitory receptor present on T cells that interacts with its ligand programmed death‐ligand 1 (PD‐L1) found on cancer cells.

Independent Predictors of Mortality Among Patients With NAFLD Hospitalized With COVID‐19 Infection

Zobair M. Younossi, Maria Stepanova, Brian Lam, Rebecca Cable, Sean Felix, Thomas Jeffers, Elena Younossi, Huong Pham, Manirath Srishord, Patrick Austin, Michael Estep, Kathy Terra, Carey Escheik, Leyla Avila, Pegah Golabi, Andrej Kolacevski, Andrei Racila, Linda Henry, Lynn Gerber – 20 July 2021 – The impact of the coronavirus disease 2019 (COVID‐19) pandemic among patients with chronic liver disease is unknown.

IL‐1β‐Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up‐regulating Programmed Death Ligand 1 and Colony‐Stimulating Factor 1

Qin He, Mei Liu, Wenjie Huang, Xiaoping Chen, Bixiang Zhang, Tongyue Zhang, Yijun Wang, Danfei Liu, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia – 19 July 2021

COVID‐19 and the Uncovering of Health Care Disparities in the United States, United Kingdom and Canada: Call to Action

Aftab Ala, Julius Wilder, Naudia L. Jonassaint, Carla S. Coffin, Carla Brady, Andrew Reynolds, Michael L. Schilsky – 19 July 2021 – The coronavirus disease 2019 (COVID‐19) pandemic created a crisis that disproportionately affected populations already disadvantaged with respect to access to health care systems and adequate medical care and treatments. Understanding how and where health care disparities are most widespread is an important starting point for exploring opportunities to mitigate such disparities, especially within our patient population with liver disease.

The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin‐Mediated Degradation of 3‐Hydroxy‐3‐Methylglutaryl CoA Reductase Degradation Protein 1

Qin Yang, Xi Chen, Yanfang Zhang, Sha Hu, Fengjiao Hu, Yongping Huang, Tengfei Ma, Heng Hu, Han Tian, Song Tian, Yan‐Xiao Ji, Zhi‐Gang She, Peng Zhang, Xiao‐Jing Zhang, Yufeng Hu, Hailong Yang, Yufeng Yuan, Hongliang Li – 16 July 2021

Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics

Magda Shaheen, Deyu Pan, Katrina M. Schrode, Dulcie Kermah, Vishwajeet Puri, Ali Zarrinpar, David Elisha, Sonia M. Najjar, Theodore C. Friedman – 15 July 2021 – Hepatic steatosis (HS) is a growing problem in adults worldwide, with racial/ethnic disparity in the prevalence of the disease. The purpose of this study was to characterize the racial/ethnic prevalence of the stages (normal/mild [S0/S1], moderate [S2], and severe [S3]) of HS in Mexican Americans and other Hispanics compared to other racial/ethnic groups.

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