Suppression of Noncoding RNAs as Shared Early Genetic Events in Multistep Hepatocarcinogenesis
Takeshi Suda, Seiichi Yoshikawa, Tsutomu Kanefuji, Satoshi Abe, Takahiro Hoshi, Shinichi Morita, Kazuyoshi Yagi, Shuji Terai – 28 July 2021
Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma
Kishor Pant, Estanislao Peixoto, Seth Richard, Aalekhya Biswas, M. Gerard O’Sullivan, Nasra Giama, Yeonjung Ha, Jun Yin, Pietro Carotenuto, Massimiliano Salati, Yanan Ren, Rendong Yang, Brunella Franco, Lewis R. Roberts, Sergio A. Gradilone – 28 July 2021
Guanine Nucleotide‐Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1–Related Inflammation and Lipophagy
Zechuan Zhang, Zetao Ji, Jianbo He, Yijun Lu, Wenfang Tian, Chang Zheng, Huihui Chen, Quan Zhang, Fei Yang, Minglu Zhang, Yin Yin, Runqiu Jiang, Wen‐Ming Chu, Wenjie Zhang, Beicheng Sun – 28 July 2021
Multidisciplinary Clinic Models: A Paradigm of Care for Management of NAFLD
Sonal Kumar, Rochelle Wong, Carolyn Newberry, Michele Yeung, Jessica M. Peña, Reem Z. Sharaiha – 28 July 2021
Leukocyte‐Derived High‐Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes
Annika Volmari, Katharina Foelsch, Elisabeth Zierz, Karsten Yan, Minyue Qi, Karlotta Bartels, Stephanie Kondratowicz, Marius Boettcher, Daniel Reimers, Masahiro Nishibori, Keyue Liu, Robert F. Schwabe, Ansgar W. Lohse, Samuel Huber, Hans‐Willi Mittruecker, Peter Huebener – 27 July 2021 – High‐mobility group box 1 (HMGB1) is a nucleoprotein with proinflammatory functions following cellular release during tissue damage.
Farnesoid X Receptor Is Required for the Redifferentiation of Bipotential Progenitor Cells During Biliary‐Mediated Zebrafish Liver Regeneration
Pengcheng Cai, Xiaoyu Mao, Jieqiong Zhao, Li Nie, Yan Jiang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo – 27 July 2021
SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR
Jingjing Song, Yupeng Liu, Juan Wan, Guang‐Nian Zhao, Jian‐Cheng Wang, Zhifei Dai, Sha Hu, Ling Yang, Zhen Liu, Yi Fu, Erdan Dong, Yi‐Da Tang – 27 July 2021
Usefulness of Cell‐Free Human Telomerase Reverse Transcriptase Mutant DNA Quantification in Blood for Predicting Hepatocellular Carcinoma Treatment Efficacy
Masaru Muraoka, Shinya Maekawa, Ryo Katoh, Yasuyuki Komiyama, Natsuko Nakakuki, Hitomi Takada, Shuya Matsuda, Yuichiro Suzuki, Mitsuaki Sato, Akihisa Tatsumi, Mika Miura, Fumitake Amemiya, Hiroko Shindo, Shinichi Takano, Mitsuharu Fukasawa, Kozue Yamauchi, Tatsuya Yamaguchi, Yasuhiro Nakayama, Taisuke Inoue, Nobuyuki Enomoto – 27 July 2021 – Although the usefulness of liquid biopsy as a biomarker in the treatment of hepatocellular carcinoma (HCC) has been suggested, its usefulness in transcatheter arterial chemoembolization (TACE) or tyrosine kinase inhibitor (TKI) therapies has not been re
Mandatory Hepatology Education for Internal Medicine Residents: Long‐Term Effects and Implications for Workforce Needs
Adam E. Mikolajczyk, Netanel Zilberstein, John F. McConville, Alex Pan, Andrew I. Aronsohn, Helen S. Te, Gautham Reddy, Sonali Paul, Anjana Pillai, Michael Charlton, Jeanne M. Farnan – 27 July 2021 – We previously created a mandatory, inpatient, hepatology resident curriculum that immediately improved comfort, knowledge, and career interest in chronic liver disease (CLD). The durability of these effects needs to be known to use this intervention to address the hepatologist shortage.
Risk Prediction of Nosocomial and Posthospital Discharge Infections in Alcohol‐Associated Hepatitis
Daniel D. Penrice, Serena Shah, Camille A. Kezer, Thoetchai Bee Peeraphatdit, Arun J. Sanyal, Brian Davis, Kristin C. Mara, Vijay H. Shah, Patrick S. Kamath, Douglas A. Simonetto – 27 July 2021 – Alcohol‐associated hepatitis (AAH) is a severe form of liver injury with mortality as high as 30%‐40% at 90 days. As a result of altered immune function in AAH, bacterial infections are common and are associated with poor outcomes. However, determining the risk and subsequent development of infection in patients with AAH remain challenging.