Tissue‐Specific Regulation of Ferroportin in Wild‐Type and Hjv‐/‐ Mice Following Dietary Iron Manipulations

Angeliki Katsarou, Konstantinos Gkouvatsos, Carine Fillebeen, Kostas Pantopoulos – 15 July 2021 – Hepcidin is a liver‐derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation. Genetic hepcidin inactivation leads to hereditary hemochromatosis, a disease of iron overload. We used wild‐type and Hjv‐/‐ mice, a model of hemochromatosis, to examine the expression of ferroportin and other proteins of iron metabolism in hepcidin target tissues.

Best Practices in Large Database Clinical Epidemiology Research in Hepatology: Barriers and Opportunities

Nadim Mahmud, David S. Goldberg, Therese Bittermann – 14 July 2021 – With advances in computing and information technology, large health care research databases are becoming increasingly accessible to investigators across the world. These rich, population‐level data sources can serve many purposes, such as to generate “real‐world evidence,” to enhance disease phenotyping, or to identify unmet clinical needs, among others.

Fatty Liver Is an Independent Risk Factor for Delayed Recovery from Anesthesia

Mark Shapses, Lin Tang, Austin Layne, Andrea Beri, Yaron Rotman – 14 July 2021 – Fatty liver (FL) is associated with altered activity of hepatic drug‐metabolizing enzymes, but the clinical significance is unknown. Many anesthetic agents are metabolized in the liver. We aimed to determine whether FL impacts recovery from anesthesia as a surrogate for altered drug metabolism. This was a single‐center, retrospective, case‐control study of all adults who underwent anesthesia and concurrent abdominal imaging (n = 2,021) in a hospital setting.

Temporal Trends and Evolving Outcomes After Simultaneous Liver‐Kidney Transplantation: Results from the US SLKT Consortium

Giuseppe Cullaro, Pratima Sharma, Jennifer Jo, Jasmine Rassiwala, Lisa B. VanWagner, Randi Wong, Jennifer C. Lai, John Magee, Aaron Schluger, Pranab Barman, Yuval A. Patel, Kara Walter, Scott W. Biggins, Elizabeth C. Verna – 14 July 2021 – We aimed to understand the contemporary changes in the characteristics and the determinants of outcomes among simultaneous liver‐kidney transplantation (SLKT) recipients at 6 liver transplantation centers in the United States. We retrospectively enrolled SLKT recipients between 2002 and 2017 in the US Multicenter SLKT Consortium.

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