Addressing Social Adversity to Improve Outcomes for Children After Liver Transplant

Sharad I. Wadhwani, Laura Gottlieb, John C. Bucuvalas, Courtney Lyles, Jennifer C. Lai – 27 July 2021 – The social determinants of health, defined as the conditions in which we live, learn, work, and play, undoubtedly impact health outcomes. Social adversity in childhood perpetuates over the life course and has consequences extending into adulthood. This link between social adversity and adverse outcomes extends to children undergoing liver transplant, with children from socioeconomically deprived neighborhoods experiencing a greater burden of morbidity and mortality after transplant.

LiverLearning®: 2021 Webinar: Genetics of NAFLD

In this webinar, you will learn how to describe nonalcoholic fatty liver disease (NAFLD) as it relates to genes in animal and human models, their role, function and related pathways. Also, the focus on NAFLD-related genes in human studies and their relationship to disease severity. Lastly, can you use the genes in a precision medicine approach?Silvia Sookoian Silvia Sookoian, MD, PhD, FAASLD is head of Clinical and Molecular Hepatology Department, Institute of Medical Research IDIM-National Scientific and Technical Research Council (CONICET), School of Medicine, University of Buenos Aires.

Molecular Mismatch Predicts T Cell–Mediated Rejection and De Novo Donor‐Specific Antibody Formation After Living Donor Liver Transplantation

Kosuke Ono, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Naoki Tanimine, Hiroaki Yamane, Hideki Ohdan – 25 July 2021 – Human leukocyte antigen (HLA) molecular mismatch (MM) analysis improves the prediction of clinical outcomes in kidney transplantation compared with prediction via traditional antigen MM. However, it remains unclear whether the level of MM can be used for risk stratification among liver transplantation (LT) recipients.

NF‐κB Regulation of LRH‐1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition–Associated Cholestasis

Swati Ghosh, Michael W. Devereaux, Aimee L. Anderson, Sarah Gehrke, Julie A. Reisz, Angelo D’Alessandro, David J. Orlicky, Mark Lovell, Karim C. El Kasmi, Colin T. Shearn, Ronald J. Sokol – 25 July 2021

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