Guanine Nucleotide‐Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1–Related Inflammation and Lipophagy

Zechuan Zhang, Zetao Ji, Jianbo He, Yijun Lu, Wenfang Tian, Chang Zheng, Huihui Chen, Quan Zhang, Fei Yang, Minglu Zhang, Yin Yin, Runqiu Jiang, Wen‐Ming Chu, Wenjie Zhang, Beicheng Sun – 28 July 2021

Leukocyte‐Derived High‐Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes

Annika Volmari, Katharina Foelsch, Elisabeth Zierz, Karsten Yan, Minyue Qi, Karlotta Bartels, Stephanie Kondratowicz, Marius Boettcher, Daniel Reimers, Masahiro Nishibori, Keyue Liu, Robert F. Schwabe, Ansgar W. Lohse, Samuel Huber, Hans‐Willi Mittruecker, Peter Huebener – 27 July 2021 – High‐mobility group box 1 (HMGB1) is a nucleoprotein with proinflammatory functions following cellular release during tissue damage.

Addressing Social Adversity to Improve Outcomes for Children After Liver Transplant

Sharad I. Wadhwani, Laura Gottlieb, John C. Bucuvalas, Courtney Lyles, Jennifer C. Lai – 27 July 2021 – The social determinants of health, defined as the conditions in which we live, learn, work, and play, undoubtedly impact health outcomes. Social adversity in childhood perpetuates over the life course and has consequences extending into adulthood. This link between social adversity and adverse outcomes extends to children undergoing liver transplant, with children from socioeconomically deprived neighborhoods experiencing a greater burden of morbidity and mortality after transplant.

Risk Prediction of Nosocomial and Posthospital Discharge Infections in Alcohol‐Associated Hepatitis

Daniel D. Penrice, Serena Shah, Camille A. Kezer, Thoetchai Bee Peeraphatdit, Arun J. Sanyal, Brian Davis, Kristin C. Mara, Vijay H. Shah, Patrick S. Kamath, Douglas A. Simonetto – 27 July 2021 – Alcohol‐associated hepatitis (AAH) is a severe form of liver injury with mortality as high as 30%‐40% at 90 days. As a result of altered immune function in AAH, bacterial infections are common and are associated with poor outcomes. However, determining the risk and subsequent development of infection in patients with AAH remain challenging.

Mandatory Hepatology Education for Internal Medicine Residents: Long‐Term Effects and Implications for Workforce Needs

Adam E. Mikolajczyk, Netanel Zilberstein, John F. McConville, Alex Pan, Andrew I. Aronsohn, Helen S. Te, Gautham Reddy, Sonali Paul, Anjana Pillai, Michael Charlton, Jeanne M. Farnan – 27 July 2021 – We previously created a mandatory, inpatient, hepatology resident curriculum that immediately improved comfort, knowledge, and career interest in chronic liver disease (CLD). The durability of these effects needs to be known to use this intervention to address the hepatologist shortage.

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