Arginine Methylation of Hepatic hnRNPH Suppresses Complement Activation and Systemic Inflammation in Alcohol‐Fed Mice

Michael Schonfeld, Maria T. Villar, Antonio Artigues, Steven A. Weinman, Irina Tikhanovich – 8 February 2021 – Protein arginine methyl transferase 1 (PRMT1) is the main enzyme for cellular arginine methylation. It regulates many aspects of liver biology including inflammation, lipid metabolism, and proliferation. Previously we identified that PRMT1 is necessary for protection from alcohol‐induced liver injury. However, many PRMT1 targets in the liver after alcohol exposure are not yet identified.

Evolving Up‐regulation of Biliary Fibrosis–Related Extracellular Matrix Molecules After Successful Portoenterostomy

Antti Kyrönlahti, Nimish Godbole, Oyediran Akinrinade, Tea Soini, Iiris Nyholm, Noora Andersson, Maria Hukkinen, Jouko Lohi, David B. Wilson, Marjut Pihlajoki, Mikko P. Pakarinen, Markku Heikinheimo – 8 February 2021 – Successful portoenterostomy (SPE) improves the short‐term outcome of patients with biliary atresia (BA) by relieving cholestasis and extending survival with native liver. Despite SPE, hepatic fibrosis progresses in most patients, leading to cirrhosis and a deterioration of liver function.

Linoleic Acid‐Derived Oxylipins Differentiate Early Stage Alcoholic Hepatitis From Mild Alcohol‐Associated Liver Injury

Dennis Warner, Vatsalya Vatsalya, Kara H. Zirnheld, Jeffrey B. Warner, Josiah E. Hardesty, John C. Umhau, Craig J. McClain, Krishnarao Maddipati, Irina A. Kirpich – 8 February 2021 – Alcohol‐associated liver disease (ALD) is a spectrum of liver disorders ranging from steatosis to steatohepatitis, fibrosis, and cirrhosis. Alcohol‐associated hepatitis (AH) is an acute and often severe form of ALD with substantial morbidity and mortality. The mechanisms and mediators of ALD progression and severity are not well understood, and effective therapeutic options are limited.

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