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5 February 2021
The Patient’s Perspective in Cirrhosis: Unmet Supportive Care Needs Differ by Disease Severity, Etiology, and Age
Patricia C. Valery, Christina M. Bernardes, Benjamin Mckillen, Samath Amarasena, Katherine A. Stuart, Gunter Hartel, Paul J. Clark, Richard Skoien, Tony Rahman, Leigh Horsfall, Kelly Hayward, Rohit Gupta, Andrew Lee, Leshni Pillay, Elizabeth E. Powell – 5 February 2021 – Patients with cirrhosis have significant physical, psychological, and practical needs. We documented patients’ perceived need for support with these issues and the differences with increasing liver disease severity, etiology, and age.
Table of contents
5 February 2021
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5 February 2021
The Impact of Direct‐Acting Antiviral Therapy on End‐Stage Liver Disease Among Individuals with Chronic Hepatitis C and Substance Use Disorders
Haesuk Park, Xinyi Jiang, Hyun Jin Song, Vincent Lo Re, Lindsey M. Childs‐Kean, Wei‐Hsuan Lo‐Ciganic, Robert L. Cook, David R. Nelson – 4 February 2021
De Novo Colorectal and Pancreatic Cancer in Liver‐Transplant Recipients: Identifying the Higher‐Risk Populations
Navine Nasser‐Ghodsi, Kristin Mara, Kymberly D. Watt – 4 February 2021
Noninvasive Tests to Phenotype Nonalcoholic Fatty Liver Disease: Sequence and Consequences of Arranging the Tools in the Tool Box
Raj Vuppalanchi, Rohit Loomba – 4 February 2021
Exosome‐Like Nanoparticles From Lactobacillus rhamnosusGG Protect Against Alcohol‐Associated Liver Disease Through Intestinal Aryl Hydrocarbon Receptor in Mice
Zelin Gu, Fengyuan Li, Yunhuan Liu, Mengwei Jiang, Lihua Zhang, Liqing He, Daniel W. Wilkey, Michael Merchant, Xiang Zhang, Zhong‐Bin Deng, Shao‐Yu Chen, Shirish Barve, Craig J. McClain, Wenke Feng – 4 February 2021 – Alcohol‐associated liver disease (ALD) is a major cause of mortality. Gut barrier dysfunction–induced bacterial translocation and endotoxin release contribute to the pathogenesis of ALD. Probiotic Lactobacillus rhamnosus GG (LGG) is known to be beneficial on experimental ALD by reinforcing the intestinal barrier function.
Nonalcoholic Fatty Liver Disease and Recent Guideline Updates
Yumi Ando, Janice H. Jou – 4 February 2021
Natural Killer Cells Regulate the Maturation of Liver Sinusoidal Endothelial Cells Thereby Promoting Intrahepatic T‐Cell Responses in a Mouse Model
Yanqin Du, Hu Yan, Shi Zou, Tanvi Khera, Jia Li, Meihong Han, Xiaoli Yang, Baoju Wang, Jia Liu, Shuilin Sun, Xin Zheng, Ulf Dittmer, Mengji Lu, Dongliang Yang, Heiner Wedemeyer, Jun Wu – 4 February 2021 – Functional maturation of liver sinusoidal endothelial cells (LSECs) plays an important role in intrahepatic T‐cell activation and control of viral infections. Natural killer (NK) cells have been reported to prompt the maturation of antigen‐presenting cells (APCs), especially for dendritic cells (DCs), but the interaction between NK cells and LSECs is elusive.