HUMAN-CORRELATED GENETIC HCC MODELS IDENTIFY COMBINATION THERAPY FOR PRECISION MEDICINE

<div><p><b>Background:</p> </b><p>Hepatocellular carcinoma (HCC) is a major cause of mortality worldwide. Providing precision medicine to patients is a key unmet need. Preclinical models, when accurately reflecting human disease, offer an opportunity to understand varying therapeutic responses between different patient groups.</p>

PRELIMINARY OFF-TREATMENT RESPONSES FOLLOWING 48 WEEKS OF VEBICORVIR, NUCLEOS(T)IDE REVERSE TRANSCRIPTASE INHIBITOR, AND AB-729 COMBINATION IN VIROLOGICALLY SUPPRESSED PATIENTS WITH HEPATITIS B E ANTIGEN NEGATIVE CHRONIC HEPATITIS B: ANALYSIS FROM AN OPEN

<div><p><b>Background:</p> </b><p>This open-label study assessed the safety and efficacy of vebicorvir (VBR)+AB-729+nucleos(t)ide reverse transcriptase inhibitor (NrtI) in virologically suppressed (VS) patients (pts) with hepatitis B e antigen (eAg) negative chronic hepatitis B infection (NCT04820686). VBR is a 1st-generation core inhibitor and AB-729 is a single trigger GalNAc-siRNA targeting all HBV RNA transcripts. Initial end of treatment (EOT) responses were previously described.

SPIRONOLACTONE THERAPY ASSOCIATES WITH REDUCED INCIDENT ALCOHOL-ASSOCIATED LIVER DISEASE IN HIGH RISK PATIENTS: A RETROSPECTIVE COHORT STUDY

<div><p><strong><b>Background:</strong> </b><span class="NormalTextRun SCXW91602795 BCX0">Effective treatment for alcohol use disorder (AUD) is the cornerstone of preventing the development of alcohol-associated liver disease (ALD).

RISK OF ADVERSE LIVER AND RENAL OUTCOMES AFTER INITIATION OF A SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITOR VS. GLP-1 RECEPTOR AGONISTS AND DIPEPTIDYL PEPTIDASE-4 INHIBITORS AMONG US ADULT PATIENTS WITH TYPE 2 DIABETES AND MASLD

<div><p><b>Background: </b>The effects of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on liver and renal outcomes in patients with type 2 diabetes mellitus (T2DM) were demonstrated in recent trials. However, the magnitude of benefits associated with underlying metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. We aimed to explore the risk of adverse liver and renal outcomes in patients with MASLD and T2DM taking SGLT-2i vs.

SLC1A5 REGULATES LIPID METABOLISM AND FORMS AN IMMUNOSUPPRESSIVE TME IN HCC

<div><p><b>Background: </b>Tumor microenvironment(TME) reflects the intertwined crosstalk between cancer cells and tumor-infiltrating immune cells, affecting the efficiency of immunotherapy. Metabolic reprogramming, one of the major hallmarks of hepatocellular carcinoma(HCC), is unclear in the aspect of reshaping TME. In this study, we report the vital role of SLC1A5, the major glutamine transporter of tumor cells, in HCC progression and the formation of immunosuppressive TME.</p>

PHOSPHATIDYLETHANOL MONITORING OF POST-TRANSPLANT ALCOHOL CONSUMPTION AMONG ALCOHOL AND NON-ALCOHOL-RELATED LIVER TRANSPLANT RECIPIENTS

<div><p><b>Background:</p> </b><p>Accurate alcohol assessments after liver transplants (LT) are crucial for understanding alcohol use and guiding treatment, particularly among LT recipients with prior alcohol-related liver disease (ALD). Biomarkers offer objective measures of alcohol exposure, but LT centers have not universally implemented routine biomarker use. Phosphatidylethanol (PEth) is a blood biomarker capable of detecting alcohol use during the prior 3-4 weeks.

DEVELOPMENT AND VALIDATION OF AN ALGORITHM FOR THE PREDICTION OF HIGH-RISK VARICES IN PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA (HCC)

<div><p><b>Background: </b>An assessment of varices is required prior to systemic therapy in patients with HCC. However, current non-invasive criteria, including the Baveno criteria, have not been validated in patients with HCC, and performing an EGD can delay HCC treatment initiation. We aimed to develop a noninvasive algorithm for assessing varices in patients with unresectable HCC.</p>

METABOLIC SYNDROME ASSOCIATED FATTY LIVER DISEASE IS A SIGNIFICANT RISK FACTOR FOR THE DEVELOPMENT OF HEPATIC EVENTS IN ALPHA-1-ANTITRYPSIN PI*ZZ INDIVIDUALS.

<div><p><b>Background:<span> </b>Patients with Alpha-1-antitrypsin Pi*ZZ homozygotes are at risk for developing liver cirrhosis and hepatocellular carcinoma. However, there is a high degree of variability in the clinical manifestations of patients with A1AT Pi*ZZ suggesting that genetic and environmental disease modifiers play an important role in the disease process. The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rising worldwide.

B CELL ACTIVATION IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS: METABOLIC SHIFTS AND IMPLICATIONS FOR ANTIGEN-SPECIFIC RESPONSES

<div><p><b>Background: </b>Metabolic dysfunction associated steatohepatitis (MASH) involves immune mechanisms and the contribution of adaptive immunity to disease progression has been increasingly recognized. B cells, with their ability to modulate inflammation, are key players in inflammatory diseases. However, their precise role and underlying mechanisms in MASH pathogenesis remain unclear. Therefore, our research aims to investigate the mechanisms driving B cell activation and their pro-inflammatory activity in MASH.</p>

DIGITAL IMAGE QUANTIFICATION OF THE ANTIFIBROTIC EFFECT OF SEMAGLUTIDE AND THE IMPACT OF LIVER FAT IN NONALCOHOLIC STEATOHEPATITIS

<div><p><b>Background:<span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB" class="TextRun SCXW196881610 BCX0"> </b><span class="NormalTextRun SCXW196881610 BCX0">Following</span><span class="NormalTextRun SCXW196881610 BCX0"> </span><span class="NormalTextRun SCXW196881610 BCX0">reductions in </span><span class="NormalTextRun SCXW196881610 BCX0">steatosis and </span><span class="NormalTextRun SCXW196881610 BCX0">bod

Subscribe to