MULTI-ANCESTRY WHOLE GENOME SEQUENCING (WGS) AND META-ANALYSIS TO IDENTIFY LOCI ASSOCIATED WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)

<div><p><b>Background: </b>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease in the US. Notably, disease prevalence differs greatly by race/ethnicity, with the highest prevalence in those of Hispanic and Asian ancestry, and the lowest prevalence in those of African ancestry. To date, studies have identified common variants associated with MASLD in predominantly European or American populations.

Introduction: Welcome and overview of the workshop

Transient Elastography 101:

  • What liver tissue properties are measured and how
  • What are the current indications for elastography examination in clinical practice 
  • When is elastography examination inappropriate? 
  • What other tests can be used if US-based elastography is not available 
  • What are the options when an examination is not technically successful 
  • What if elastography results conflict with findings on other clinical examinations


 

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