MULTI-ANCESTRY WHOLE GENOME SEQUENCING (WGS) AND META-ANALYSIS TO IDENTIFY LOCI ASSOCIATED WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)

<div><p><b>Background: </b>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease in the US. Notably, disease prevalence differs greatly by race/ethnicity, with the highest prevalence in those of Hispanic and Asian ancestry, and the lowest prevalence in those of African ancestry. To date, studies have identified common variants associated with MASLD in predominantly European or American populations.

THE RISK OF LIVER FIBROSIS IS GREATEST IN AREAS OF HIGHER SOCIOECONOMIC DEPRIVATION: A RISK-FACTOR BASED POPULATION SCREENING STUDY.

<div><p><b>Background:</p> </b><p>Early detection of liver disease has been identified as a public health priority in the UK. Symptoms are rare before advanced stages and case finding using risk factors improves identification. In financially constrained health systems, case finding in areas with greater disease burden is prudent. Socio-economic deprivation is associated with advanced liver disease. We assessed the incidence of liver disease by population deprivation using a community case finding pathway.</p>

ROLE OF AUTOPHAGY IN HEPATIC ACETYLOME REGULATION

<div><p><b>Background: </b>Liver acetylome is a set of protein acetylation’s whose level reflects cellular metabolic health and is directly linked to intracellular pathways. However, to date, little is known about the cellular pathways that maintain the hepatic acetylome levels. Here, we show that macroautophagy hereafter referred to as autophagy, an intracellular lysosomal degradative pathway, regulates the hepatic acetylome.</p>

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