<div><p><b>Background: </b>Pediatric acute liver failure (PALF) remains a poorly-characterized disease entity that affects children of all ages. Emerging data supports an underlying immune-mediated process driving progression and severity. Up to 25% of patients will require liver transplantation (LT), yet there are no reliable indicators of disease trajectory to guide clinicians. </p>

<div><p><b>Background: </b>H<span>epatic stellate cells (HSCs) are the main drivers of liver fibrosis. During The Liver Meeting 2022, we demonstrated that glycolysis deficiency selectively in HSCs attenuated liver fibrosis <em>in vivo</em>. The aim of the present study is to understand how HSC-specific glycolysis promotes liver fibrosis by altering signaling pathways and HSC interactions with the surrounding cell types in a spatial manner.</span></p>

<div><p><b>Background:</p> </b><p>As the prevalence of obesity and MASH continues to grow, novel treatment options are needed to prevent progression as there are currently no medications approved to treat MASH. Weight loss has been shown to be an effective treatment with a 5% weight loss reversing steatosis and a 10% weight loss reversing liver fibrosis. Clinical trials using lifestyle-based weight loss interventions in MASH have been shown to achieve &gt;5% total body weight loss (TBWL) in 30% of patients and &gt;10% TBWL in 10% of patients.

<div><p><strong><b>Background:</strong> </b></p>

<div><p><b>Background:</p> </b><p>Cirrhosis now has the 10th highest mortality rate worldwide. Most cirrhosis deaths are caused by the emergence of clinical decompensation, and 4%–12% of those who have the disease, experience at least one episode of decompensation per year<strong>.</strong> These patients are highly susceptible to infections due to increased systemic inflammation leading to kidney failure and death.

<div><p><b>Background:</p> </b><p>Continuous renal replacement therapy (CRRT) is the preferred mode of dialysis in critically ill hemodynamically unstable patients and in addition removes the inflammatory cytokines that accumulate in sepsis. Sustained low-efficiency dialysis (SLED) is a hybrid modality of intermittent dialysis with the advantage of metabolic control, hemodynamic stability, at a reduced cost.

<div><p><strong><span><b>Background:</span> </b></strong><span> Circulating tumor DNA (ctDNA) is a promising non-invasive biomarker in cancer management. We aimed to assess the dynamic evolution of ctDNA in patients with hepatocellular carcinoma (HCC).</span></p>

<div><p><strong>Background</strong>:</p>

<div><p><b>Background: </b>Hepatic cholesterol accumulation and hypercholesterolemia are considered as the risk factors of hepatocellular carcinoma (HCC).<strong> </strong>However,<strong> </strong>the therapeutic effects of cholesterol lowering drugs for the treatment of HCC are controversial, indicating that the relationship between cholesterol metabolism and HCC is more complex than anticipated.</p>

<div><p><b>Background: </b>Hepatitis B surface Antigen (HBsAg) loss occurs in a minor fraction of patients with Chronic Hepatitis B (CHB) under interferon therapy. Identifying the host factors critical for CHB cure can help recognize those who would benefit from interferon therapy.</p>