Key risk factors for development of drug-induced liver injury (DILI), especially genetic factors like HLA associations, are the focus of this lecture. Speakers will explore other genetic risk factors that may contribute to DILI and discuss recent data showing how the non-HLA gene PTPN22 may contribute to DILI due to the use of a number of different drugs.
Manhal Izzy, Lisa B. VanWagner, Grace Lin, Mario Altieri, James Y. Findlay, Jae K. Oh, Kymberly Watt, Samuel S. Lee, the Cirrhotic Cardiomyopathy Consortium: The Cirrhotic Cardiomyopathy Consortium is a multidisciplinary international group whose focus is to improve the understanding of cirrhotic cardiomyopathy, its management and outcomes – 11 November 2019
Anoop N. Koshy, Omar Farouque, Paul Calafiore, Paul J. Gow – 11 November 2019
The Diversity and Inclusion Committee promotes health disparities research and efforts to improve health outcomes among ethnic and racial groups who carry a higher burden of liver disease. Based on positive feedback from the 2018 workshop on Ethnic and Racial Disparities in Liver Disease, this two-hour workshop reviews current programmatic efforts to eliminate disparate outcomes in liver disease and liver transplantation.
In the world's poorest nations, the appalling loss of life from easily treated or preventable illnesses represents a moral tragedy. This year's President's Choice Lecture explores potential strategies to correct this inequity, including collaborative partnerships among medical professionals, ways to accurately measure the impact of global disease management efforts and the innovative solutions necessary to accomplish this great task.
Patient and caregiver education, and transition to care are important aspects for hospital discharge. At this informative program, experts will review multidisciplinary strategies to optimize discharge planning and share innovative models of outpatient care in liver disease, including empowering patients and caregivers, decreasing risk factors and the incidence of hospital readmissions, and reducing costs.
Acute on Chronic Liver Failure (ACLF) is a well-recognized rapid course of liver disease that can have devastating consequences on patients. At this symposium, faculty will discuss ACLF’s common triggers and explore current perspectives of management in the context of these triggering events. Topics covered include microbiome analysis to identify high-risk patients and the role of transplantation.
Review data from ongoing clinical trials for alcoholic hepatitis, explore the role of early liver transplantation and discuss the management of alcohol use disorder in patients with alcoholic hepatitis and acute on chronic liver failure. Topics covered include trial design considering standards of care and liver transplantation’s emerging role and subject recruitment challenges for clinical trials in alcoholic hepatitis.
Immunosuppression in the liver transplant setting includes multiple drugs aimed at predetermined trough levels, adjusted to time after transplantation. Excellent graft and patient survival supports immunosuppression, but there may be significant short- and long-term risks. At this presentation, experts will discuss clinical approaches to immunosuppression in liver transplant patients, including biomarkers used for safe personalization of this process.
Several NIH institutes showcase programs, innovations and opportunities to the AASLD membership at this informative event. Representatives of the NCI, NIDDK, NIAID and NIAAA will present areas of mutual interest to the institute and AASLD membership, including liver cancer, NASH, viral hepatitis and alcohol use disorder. This is a unique opportunity to learn more about interagency collaboration and funding opportunities.