Activation of WNT/Beta‐Catenin Signaling and Regulation of the Farnesoid X Receptor/Beta‐Catenin Complex After Murine Bile Duct Ligation
Rong Zhang, Toshimasa Nakao, Jing Luo, Yuhua Xue, Pamela Cornuet, Michael Oertel, Karis Kosar, Sucha Singh, Kari Nejak‐Bowen – 14 October 2019 – We have recently shown that loss of β‐catenin prevents the development of cholestatic liver injury and fibrosis after bile duct ligation (BDL) due to loss of the inhibitory farnesoid X receptor (FXR)/β‐catenin complex, which results in decreased hepatic bile acids (BAs) through activation of FXR.