Increased Frequency of Heterozygous Alpha‐1‐Antitrypsin Deficiency in Liver Explants From Nonalcoholic Steatohepatitis Patients
Gregory Cheeney, Lincoln J. Pac, Purva Gopal, Charles S. Landis, Eric Q. Konnick, Paul E. Swanson, Dina N. Greene, Christina M. Lockwood, Maria Westerhoff – 9 October 2019 – Cirrhotic explanted livers occasionally have unexpected periodic acid–Schiff‐diastase (PASD)–positive globules within the hepatocyte cytoplasm. It is often unclear whether this finding is a nonspecific consequence of cirrhosis or is indicative of an underlying alpha‐1‐antitrypsin deficiency (A1ATD) contributing to the cirrhosis.