Interleukin‐32 Contributes to Human Nonalcoholic Fatty Liver Disease and Insulin Resistance

Nassim Dali‐Youcef, Michel Vix, Federico Costantino, Houssein El‐Saghire, Benoit Lhermitte, Cosimo Callari, Jacopo D’Agostino, Silvana Perretta, Stefan Paveliu, Monica Gualtierotti, Edith Dumeny, Marine A. Oudot, Amélie Jaulin, Doulaye Dembélé, Mirjam B. Zeisel, Catherine Tomasetto, Thomas F. Baumert, Michel Doffoël – 19 July 2019 – Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder due to increased accumulation of fat in the liver and in many cases to enhanced inflammation.

Liver Proliferation Is an Essential Driver of Fibrosis in Mouse Models of Nonalcoholic Fatty Liver Disease

Ashley Cast, Meenasri Kumbaji, Amber D'Souza, Katherine Rodriguez, Anita Gupta, Rebekah Karns, Lubov Timchenko, Nikolai Timchenko – 17 July 2019 – Nonalcoholic fatty liver disease (NAFLD) involves development of hepatic steatosis, fibrosis, and steatohepatitis. Because hepatic steatosis appears first in NAFLD animal models, the current therapy development focuses on inhibition of hepatic steatosis, suggesting that further steps of NAFLD will be also inhibited. In this report, we show that the first event of NAFLD is liver proliferation, which drives fibrosis in NAFLD.

Subscribe to