Attitudes of Liver Transplant Candidates Toward Organs From Increased‐Risk Donors

Sapna S. Humar, Jingqian Liu, Natalia Pinzon, Deepali Kumar, Mamatha Bhat, Les Lilly, Nazia Selzner – 4 April 2019 – Increased‐risk donor (IRD) organs make up a significant proportion of the deceased organ donor pool but may be declined by patients on the waiting list for various reasons. We conducted a survey of patients awaiting a liver transplant to determine the factors leading to the acceptance of an IRD organ as well as what strategies could increase the rate of acceptance.

Chronic Kidney Disease After Liver Transplantation: Impact of Extended Criteria Grafts

Marit Kalisvaart, Andrea Schlegel, Palak J. Trivedi, Keith Roberts, Darius F. Mirza, Thamara Perera, John I. Isaac, James Ferguson, Jeroen Jonge, Paolo Muiesan – 4 April 2019 – The use of extended criteria donor (ECD) grafts has been associated with acute kidney injury (AKI) after liver transplantation. However, the relation between graft quality and development of chronic kidney disease (CKD) remains unknown. Therefore, the aim of this study was to analyze the impact of ECD grafts for CKD after liver transplantation.

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Silvia Nardelli, Stefania Gioia, Lorenzo Ridola, Alessio Farcomeni, Manuela Merli, Oliviero Riggio – 4 April 2019

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Megan G. Hofmeister, Brian R. Edlin, Eli S. Rosenberg, Elizabeth M. Rosenthal, Laurie K. Barker, Meredith A. Barranco, Eric W. Hall, Jonathan Mermin, A. Blythe Ryerson – 4 April 2019

The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled

Victor Navarro, Bharathi Avula, Ikhlas Khan, Manisha Verma, Leonard Seeff, Jose Serrano, Andrew Stolz, Robert Fontana, Jawad Ahmad – 3 April 2019 – The U.S. Drug Induced Liver Injury Network assayed the contents of herbal and dietary supplements collected from patients enrolled into its prospective study. The aim was to determine the accuracy of product labels, and to identify known hepatotoxins. Using high‐performance liquid chromatography coupled with mass spectrometry to assay 272 product, 51% were found to be mislabeled; that is, to have chemical contents that did not match the label.

A Back‐to‐Base Experience of Human Normothermic Ex Situ Liver Perfusion: Does the Chill Kill?

Mariusz Bral, Khaled Dajani, Dayne Leon Izquierdo, David Bigam, Norman Kneteman, Carlo D. L. Ceresa, Peter J. Friend, A. M. James Shapiro – 2 April 2019 – Normothermic machine perfusion (NMP) has been shown to protect livers from injury between procurement and transplantation in a randomized controlled trial, where the machine was transported to and from the donor center. The aim of this study was to determine whether an alternative, more practical back‐to‐base approach after initial static cold storage would compromise beneficial outcomes.

Serum Liver‐Type Fatty Acid–Binding Protein Is a Possible Prognostic Factor in Human Chronic Liver Diseases From Chronic Hepatitis to Liver Cirrhosis and Hepatocellular Carcinoma

Akiko Eguchi, Hiroshi Hasegawa, Motoh Iwasa, Yasuyuki Tamai, Keiichi Ohata, Tsuyoshi Oikawa, Takeshi Sugaya, Yoshiyuki Takei – 2 April 2019 – Liver‐type fatty acid–binding protein (L‐FABP) is a key regulator of fatty acid metabolism, but serum L‐FABP levels are not well investigated in chronic liver diseases. We aimed to elucidate the prognostic ability of serum L‐FABP in human chronic liver diseases and compare it with the albumin‐bilirubin (ALBI) score.

Characteristics of Impaired Dendritic Cell Function in Patients With Hepatitis B Virus Infection

Atsushi Yonejima, Eishiro Mizukoshi, Toshikatsu Tamai, Hidetoshi Nakagawa, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Hikari Okada, Taro Yamashita, Yoshio Sakai, Masao Honda, Shuichi Kaneko – 2 April 2019 – Dendritic cells (DCs) are antigen‐presenting cells with a central role in host immune response. This study analyzed gene expression and DC function in hepatitis B virus (HBV) patients, functions impaired because of HBV, and identified the genes related to these functions.

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