Akiko Eguchi, Hiroshi Hasegawa, Motoh Iwasa, Yasuyuki Tamai, Keiichi Ohata, Tsuyoshi Oikawa, Takeshi Sugaya, Yoshiyuki Takei – 2 April 2019 – Liver‐type fatty acid–binding protein (L‐FABP) is a key regulator of fatty acid metabolism, but serum L‐FABP levels are not well investigated in chronic liver diseases. We aimed to elucidate the prognostic ability of serum L‐FABP in human chronic liver diseases and compare it with the albumin‐bilirubin (ALBI) score.

Atsushi Yonejima, Eishiro Mizukoshi, Toshikatsu Tamai, Hidetoshi Nakagawa, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Hikari Okada, Taro Yamashita, Yoshio Sakai, Masao Honda, Shuichi Kaneko – 2 April 2019 – Dendritic cells (DCs) are antigen‐presenting cells with a central role in host immune response. This study analyzed gene expression and DC function in hepatitis B virus (HBV) patients, functions impaired because of HBV, and identified the genes related to these functions.

Sadhana Shankar, Joseph Valamparampil, Ashwin Rammohan, Deepashree Thiruchunapalli, Mettu S. Reddy, Naresh Shanmugam, Mohamed Rela – 2 April 2019

Mariusz Bral, Khaled Dajani, Dayne Leon Izquierdo, David Bigam, Norman Kneteman, Carlo D. L. Ceresa, Peter J. Friend, A. M. James Shapiro – 2 April 2019 – Normothermic machine perfusion (NMP) has been shown to protect livers from injury between procurement and transplantation in a randomized controlled trial, where the machine was transported to and from the donor center. The aim of this study was to determine whether an alternative, more practical back‐to‐base approach after initial static cold storage would compromise beneficial outcomes.

George N. Ioannou, Charles S. Landis, Ga‐Young Jin, W. Geoffrey Haigh, Geoffrey C. Farrell, Rahul Kuver, Sum P. Lee, Christopher Savard – 1 April 2019 – It is unclear what drives the development of fibrosing nonalcoholic steatohepatitis (NASH). We aimed to determine whether cholesterol crystallization within hepatocyte lipid droplets (LDs) distinguishes patients with fibrosing NASH from patients with isolated hepatic steatosis and to study pathways leading to cholesterol accumulation in hepatocyte LDs.

Shao‐Lai Zhou, Dan Yin, Zhi‐Qiang Hu, Chu‐Bin Luo, Zheng‐Jun Zhou, Hao‐Yang Xin, Xin‐Rong Yang, Ying‐Hong Shi, Zheng Wang, Xiao‐Wu Huang, Ya Cao, Jia Fan, Jian Zhou – 1 April 2019 – Tumor‐associated neutrophils (TANs) play a crucial role in tumor development and progression in the cancer microenvironment. Despite increased understanding of TAN contributions to hepatocellular carcinoma (HCC) progression and prognosis, the direct interaction between TANs and HCC cells is not fully understood.

Susanna Naggie, Christian B. Ramers – 1 April 2019

Kiran V.K. Koelfat, Mark P. Plummer, Frank G. Schaap, Martin Lenicek, Peter L.M. Jansen, Adam M. Deane, Steven W.M. Olde Damink – 1 April 2019 – Critical illness is associated with a disturbed regulation of gastrointestinal hormones resulting in functional and metabolic anomalies. Fibroblast growth factor 19 (FGF19) is an ileum‐derived metabolic hormone induced by bile salts upon gallbladder emptying after enteral nutrient stimulation. Our aim was to study the nutrient‐stimulated FGF19 response in 24 patients admitted to the intensive care unit (ICU) compared with 12 healthy controls.

Avinash Thakur, Jasper C.H. Wong, Evan Y. Wang, Jeremy Lotto, Donghwan Kim, Jung‐Chien Cheng, Matthew Mingay, Rebecca Cullum, Vaishali Moudgil, Nafeel Ahmed, Shu‐Huei Tsai, Wei Wei, Colum P. Walsh, Tabea Stephan, Misha Bilenky, Bettina M. Fuglerud, Mohammad M. Karimi, Frank J. Gonzalez, Martin Hirst, Pamela A. Hoodless – 1 April 2019 – Cell‐fate determination is influenced by interactions between master transcription factors (TFs) and cis‐regulatory elements.

1 April 2019