Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

Runping Liu, Xiaojiaoyang Li, Weiwei Zhu, Yanyan Wang, Derrick Zhao, Xuan Wang, Emily C. Gurley, Guang Liang, Weidong Chen, Guanhua Lai, William M. Pandak, H. Robert Lippman, Jasmohan S. Bajaj, Phillip B. Hylemon, Huiping Zhou – 15 April 2019 – Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte‐derived exosomal long noncoding RNA‐H19 (lncRNA‐H19) plays a critical role in promoting cholestatic liver injury.

Predictive Value of Hepatic Venous Pressure Gradient for Graft Hemodynamics in Living Donor Liver Transplantation

Hajime Matsushima, Masato Fujiki, Kazunari Sasaki, Daniel M. Rotroff, Mark Sands, Maria Del Pilar Bayona Molano, Federico Aucejo, Teresa Diago Uso, Bijan Eghtesad, Charles Miller, Cristiano Quintini, Koji Hashimoto – 13 April 2019 – The hepatic venous pressure gradient (HVPG) measurement is known to correlate with the severity of portal hypertension in patients with liver cirrhosis.

A Single‐Center Experience on Outcomes of Complementary and Alternative Medicine Use Among Patients With Cirrhosis

Cyriac Abby Philips, Rajaguru Paramaguru, Philip Augustine, Sasidharan Rajesh, Rizwan Ahamed, Tom George, Guruprasad Padsalgi – 12 April 2019 – Drug‐induced liver injury (DILI) due to complementary and alternative medicine (CAM) use is on the rise throughout the world by patients looking for “safer” alternatives. However, data on acute‐on‐chronic liver failure (ACLF) due to CAM are lacking. In a large cohort of patients with cirrhosis, we retrospectively studied CAM‐related health‐seeking behavior and attempted to identify those who developed possible CAM‐DILI‐related ACLF.

Hepatology Highlights

Hirsh D. Trivedi, Daryl T.Y. Lau, Tasha B. Kulai, Harmeet Malhi, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nicholas Russo, Kavitha M. Nair, Giorgio Roccaro, Petra Hirsova, Vikas Gupta, Xu Xu, Tibor Krisko, Enis Kostallari – 12 April 2019

Optimal Biliary Drainage for Patients With Biliary Anastomotic Strictures After Right Lobe Living Donor Liver Transplantation

Min Su You, Woo Hyun Paik, Young Hoon Choi, Bang‐sup Shin, Sang Hyub Lee, Ji Kon Ryu, Yong‐Tae Kim, Kyung‐Suk Suh, Kwang‐Woong Lee, Nam‐Joon Yi, Suk Kyun Hong – 12 April 2019 – Right lobe (RL) living donor liver transplantation (LDLT) usually includes 2 bile duct anastomosis sites, namely, the right anterior and the right posterior segmental ducts. This study aimed to evaluate the optimal treatment for biliary strictures following RL LDLT with respect to unilateral or bilateral drainage techniques.

Hepatology Highlights

Hirsh D. Trivedi, Daryl T.Y. Lau, Tasha B. Kulai, Harmeet Malhi, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nicholas Russo, Kavitha M. Nair, Giorgio Roccaro, Petra Hirsova, Vikas Gupta, Xu Xu, Tibor Krisko, Enis Kostallari – 12 April 2019

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